Sökning: "SC-islets"

Hittade 3 avhandlingar innehållade ordet SC-islets.

  1. 1. PET imaging of beta-cell mass

    Författare :Pierre Cheung; Olof Eriksson; Weibo Cai; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PET imaging; diabetes; beta-cell mass; affibody; SC-islets; Medicinal Chemistry; Läkemedelskemi;

    Sammanfattning : A hallmark of diabetes is the progressive loss of the beta-cell mass (BCM) and function. Most of the diagnostic methods for diabetes are mostly reflective of the beta-cell function, whereas current methodologies for studying the beta-cell mass are limited to post-mortem biopsies or highly invasive methods. LÄS MER

  3. 2. Transplantation of stem cell-derived islets as a treatment for type 1 diabetes

    Författare :Julia Thorngren; Joey Lau Börjesson; Per-Ola Carlsson; Lena Eliasson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; Islet of Langerhans; Stem cell-derived islets; Islet transplantation; Humanized mouse model; Positron emission tomography; Nanofiltration; Fysiologi; Physiology; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Type 1 diabetes (T1D) is an autoimmune disease that leads to an immune attack on insulin-producing beta cells, necessitating lifelong insulin therapy. For individuals with brittle diabetes and poor metabolic control, the option of pancreatic human islet transplantation exists. LÄS MER

  4. 3. Physiological Studies of Native and Stem Cell-Derived Islets

    Författare :Daniel Norman; Per-Ola Carlsson; Daniel Espes; Helge Ræder; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Irisin; CART; Islet blood flow; Islets of Langerhans; Stem cell-derived islets; Fysiologi; Physiology; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : In type 1 and type 2 diabetes, the β-cells of the islets of Langerhans are either destroyed by the immune system or stressed due to peripheral insulin resistance. To improve the life of patients with these diseases, new treatments are needed. LÄS MER