Sökning: "Radionuclide imaging"

Visar resultat 16 - 20 av 88 avhandlingar innehållade orden Radionuclide imaging.

  1. 16. Tumour Targeting Using Radiolabelled EGF Conjugates : Preclinical Studies

    Författare :Åsa Liljegren Sundberg; Jörgen Carlsson; Lars Gedda; Vladimir Tolmachev; Erik Blomquist; Gregory P. Adams; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radiation sciences; targeting; tumour; EGF; radionuclide; gefitinib; Iressa; ZD1839; glioma; therapy; diagnostics; Strålningsvetenskap; Radiation biology; Strålningsbiologi;

    Sammanfattning : Tumour targeted radiotherapy is an appealing approach for treatment of disseminated tumour cells. A targeting agent that specifically binds to a structure on tumour cells is then used to transport therapeutically relevant radionuclides. The epidermal growth factor receptor, EGFR, is overexpressed on tumour cells in several malignancies, e.g. LÄS MER

  3. 17. Affibody-Based Molecular Imaging and Targeted Therapy of HER3-Expressing Cancer

    Författare :Sara Sophie Rinne; Anna Orlova; Vladimir Tolmachev; Mohamed Altai; Anzhelika Vorobyeva; Melpomeni Fani; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular Imaging; PET; SPECT; Cancer; Affibody; HER3; Targeted Therapy;

    Sammanfattning : The human epidermal growth factor receptor type 3 (HER3) is overexpressed in different types of cancer and is a known contributor to disease progression and resistance to cancer therapy. This thesis is based on five original articles, which aimed to improve the diagnostic and therapeutic potential of affibody-based agents for management of HER3-expressing cancers. LÄS MER

  4. 18. Cardiac involvement in familial amyloidosis with polyneuropathy

    Författare :Peter Eriksson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amyloidosis; arrhythmias; cardiac pacing; cardiac radionuclide; imaging; echocardiography; electrocardiography; pathology;

    Sammanfattning : Familial amyloidosis with polyneuropathy (FAP) is a neuropathic form of heredofamilial systemic amyloidosis. Clusters of patients have been reported predominantly from Portugal, Japan and Sweden. The present study examines the involvement of the heart in individuals with the Swedish variety of FAP. LÄS MER

  5. 19. Methods for image-based dosimetry and radiobiological modelling in radionuclide therapy

    Författare :Johan Gustafsson; Lund Medicinsk strålningsfysik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; radionuclide therapy; dosimetry; biologically effective dose; 177Lu-DOTATATE;

    Sammanfattning : In radionuclide therapy (RNT), radioactive pharmaceuticals are administered for therapeutic purposes. Dosimetry, i.e. the estimation of the absorbed dose to various targets, can potentially lead to a better understanding of the therapeutic effects in RNT and allow for individualization of the therapy. LÄS MER

  7. 20. Activity quantification based on scintillation camera imaging - Application to 111In/90Y radioimmunotherapy

    Författare :David Minarik; Lund Medicinsk strålningsfysik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radioimmunotherapy; bremsstrahlung imaging; activity quantification; SPECT; conjugate view; Yttrium;

    Sammanfattning : Radionuclide therapy (RNT), is important for the treatment of certain benign and malignant diseases. 90Y-Zevalin™ therapy has become an established method of treating patients with non-Hodgkin B-cell lymphoma. LÄS MER