Sökning: "RAFT"

Visar resultat 16 - 20 av 33 avhandlingar innehållade ordet RAFT.

  1. 16. Regulation of non-responsiveness and death in cytotoxic T cells by the agonistic potency of MHC : peptide ligands

    Författare :Michael Uhlin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :CD8 T cells; APL; CTLs; non-responsiveness; AICD; lck; lipid rafts; partial agonism; TCR activation.;

    Sammanfattning : CD8+ T lymphocytes are important for immunological control of infections and tumors. The key interaction required to initiate the process of T cell activation is the engagement of the T cell receptor (TCR) with a major histocompatibility complex (MHC) class I/peptide complex on an antigen presenting cell (APC). LÄS MER

  3. 17. Vpu-mediated intracellular targeting of HIV-1 core protein precursor Pr55[gag] and association of Pr55[gag] with lipid microdomains

    Författare :Kirsi Harila; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : HIV-1 has been suggested to use lipid rafts for assembly and budding. Lipid rafts can be separated from the bulk membranes by extraction with non-ionic detergents, such as Triton X-100 at cold, followed by a density gradient centrifugation. LÄS MER

  4. 18. Mechanoregulation of angiopoietin-like 4 in epithelial-mesenchymal transition and cancer metastasis

    Författare :Zehuan Liao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The epithelial-mesenchymal transition (EMT) serves as a pivotal mechanism in the progression of metastatic cancer. However, current research, predominantly reliant on 2D monolayer cultures, inadequately replicates the intricate nature of a 3D tumor microenvironment. LÄS MER

  5. 19. Adaptation to microenvironmental stress in glioblastoma. Mechanistic studies and potential targets

    Författare :Myriam Cerezo-Magaña; Tumörmikromiljö; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Glioblastoma; Tumor microenvironment; EVs; Proteoglycans; Tumor Surfaceome;

    Sammanfattning : Although the overall mortality in cancer is steadily decreasing, major groups of patients still respond poorly to available treatments. The key clinical challenge addressed in the present thesis work relates to the inherent adaptive capacity of glioblastoma (GBM) tumors, resulting in treatment resistance and dismal prognosis. LÄS MER

  7. 20. Surface Modification of Cellulose by Covalent Grafting and Physical Adsorption

    Författare :Linn Carlsson; Anna Carlmark; Eva Malmström; M. Naceur Belgacem; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Surface modification; cellulose; covalent modification; physical adsorption; polymer synthesis;

    Sammanfattning : The interest in new environmentally friendly cellulose‐based productshas increased tremendously over the last years. At the same time theSwedish forest industry faces new challenges in its strive to increase the utilization of cellulose fibers in high‐value end‐products. LÄS MER