Sökning: "Protein aggregation"
Visar resultat 11 - 15 av 325 avhandlingar innehållade orden Protein aggregation.
11. Protein-Surfactant Interactions in Complex Systems : Study of Physical Stability of Proteins and Peptides
Sammanfattning : My objective has been to characterize protein-surfactant interactions in pharmaceutically relevant formulations. Thus, the behavior of selected excipients, proteins and peptides has been studied as the system in question is driven to the verge of instability in different manners; by inducing aggregation, by inducing surfactant complexation, or by inducing precipitation by increasing ionic strength in the presence of preservative. LÄS MER
12. Whey protein adsorption and aggregation on modified stainless steel surfaces in relation to fouling
Sammanfattning : This thesis focuses on the possibilities to reduce fouling by 1.Modifying the stainless steel surface. LÄS MER
13. Structure and Phase Behavior of Protein Solutions
Sammanfattning : The complexity of proteins is reflected in the structure of their fluids. This is seen from strongly inhomogeneous distributions about the single protein. Using molecular simulations of protein models, based on experimental structures, the present work probes the directional forces between proteins. LÄS MER
14. Protein-protein interactions in model systems : design, control of catalytic activity and biosensor applications
Sammanfattning : This thesis describes the design of polypeptides, unordered in the monomeric state but capable of folding into helix-loop-helix motifs and dimerise to form four-helix bundles. The goal of the design was to encode them with the capacity to form dimers highly selectively and the ability to carry out molecular functions in the folded state but not in the unordered state, and thus to establish a molecular link between recognition and function. LÄS MER
15. On the molecular mechanisms of the amyloid β-peptide aggregation
Sammanfattning : The pathogenesis of Alzheimer’s disease is widely believed to be due to production and deposition of the amyloid β-peptide. Several variants of the Aβ peptide are known to exist in in vivo. Variations include mutations or additional functional groups attached to residue side chains and may affect the aggregation process. LÄS MER
