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1. 1. Functions of platelet-derived growth factor-A during organogenesis

   Författare :Linda Karlsson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; platelet-derived growth factor-A; knockout; mouse organogenesis; epithelial-mesenchymalinteractions; skin; hair follicles; CNS; lung; gastrointestinal villus;

   Sammanfattning : The formation of organs during embryonic development is calledorganogenesis. This process is regulated by the genes residing in the genome. LÄS MER

3. 2. Platelet-derived growth factor-induced signal transduction

   Författare :Sigrídur Valgeirsdóttir; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Cellbiologi; Cell biology; Cellbiologi; molekylär cellbiologi; Molecular Cellbiology;

   Sammanfattning : Platelet-derived growth factor (PDGF), a potent mitogen for mesenchymal cells, elicits its effects by binding to cell surface tyrosine kinase receptors, denoted α- and β-receptors. This thesis describes the mechanism of interaction between stimulated PDGF receptors and various intracellular molecules. LÄS MER

4. 3. Regulation of the platelet-derived growth factor β-receptor

   Författare :Catrin Molander; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF; inflammation; TNF-a; tyrosine kinase; medulloblastoma; Myc; NF-Y; Sp1;

   Sammanfattning : Growth factors are important signalling molecules, regulating cell growth, as well as cell movement, differentiation and apoptosis. They bind to specific receptors on the cell surface causing activation of the receptors. Activated receptors then attract adaptor molecules that brings the signal further into the cell. LÄS MER

5. 4. Tissue Factor Biological Functions : Coagulation Activity in Microparticles and Signaling with Focus On Migration and Apoptosis

   Författare :Mikael Åberg; Agneta Siegbahn; Carl-Henrik Heldin; Teet Velling; Björn Dahlbäck; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tissue factor; Apoptosis; Migration; Chemotaxis; Simvastatin; Platelet Derived Growth Factor; Cell Signaling; Microparticles; Prostasomes; Trombosis; Coagulation; Prostate Cancer; Breast Cancer; Caspase-3; Caspase-8; NFkappaB; PAR2; Transactivation; Monocytes; Clinical chemistry; Klinisk kemi;

   Sammanfattning : Background: Tissue factor (TF) is a 47 kDa transmembrane glycoprotein known as the main initiator of blood coagulation. TF is over-expressed on many malignant cells and apart from increasing the risk of thrombosis, the presence of TF/FVIIa also promotes the progression of cancer and metastasis by intracellular signaling. LÄS MER

7. 5. Transcriptional Regulation of the Platelet-Derived Growth Factor beta-receptor

   Författare :Anders Hackzell; Göteborgs universitet; []
   Nyckelord :PDGF; cell cycle; p73; p53; SV40; NF-Y; Sp1; Myc;

   Sammanfattning : The Platelet Derived-Growth Factor (PDGF) receptors and ligands are expressed in cells of predominantly mesenchymal origin. Binding of the ligands to the receptors stimulates cell proliferation and other cellular responses such as differentiation and cell movement. LÄS MER