Sökning: "Phosphodiesterase"

Visar resultat 21 - 25 av 66 avhandlingar innehållade ordet Phosphodiesterase.

  1. 21. Molecular Screening for Target Discovery in Cancer

    Författare :Mårten Fryknäs; Anders Isaksson; Ulf Pettersson; Hugh Salter; Uppsala universitet; []
    Nyckelord :Genetics; Cancer; Drug resistance; Microarray; High-throughput screening; Genetik;

    Sammanfattning : Cancer is one of the major causes of death in the western world. Resistance to anti-cancer drugs and diagnostic difficulties are major obstacles to successful treatment. LÄS MER

  3. 22. Mimicking the action of ribonucleases : studies on RNase A and design of PNA based artificial enzymes

    Författare :Alice Ghidini; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : A 3’-deoxy-3’-C-methylenephosphonate modified diribonucleotide is highly resistant to degradation by spleen phosphodiesterase and not cleaved at all by snake venom phosphodiesterase. Despite that both the vicinal 2-hydroxy nucleophile and the 5’-oxyanion leaving group are intact, the 3’-methylenephosponate RNA modification is also highly resistant towards the action of RNase A. LÄS MER

  4. 23. Genetics of type 2 diabetes and the metabolic syndrome

    Författare :Mia Klannemark; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetology; secreting systems; Endocrinology; PDE3B; PPARG; LPL; metabolic syndrome; diabetes; genetic; HSL; UCP2; Endokrinologi; sekretion; diabetologi;

    Sammanfattning : Type 2 diabetes and the metabolic syndrome are highly prevalent disorders with severe complications such as cardiovascular disease. The aetiology of type 2 diabetes and the metabolic syndrome is not known, but the interaction between genetic factors and environmental triggers is important. LÄS MER

  5. 24. Melanophore signaling : regulation and application

    Författare :Tony P. M. Andersson; Ethan Lerner; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Melanophores are pigment-containing cells responsible for quick physiological color changes in lower vertebrates due to redistribution of melanosomes, pigment granules. We have studied melanophores from African clawed frog, Xenopus laevis. LÄS MER

  7. 25. Functional Aspects of the Juxtaglomerular Apparatus : Control of Glomerular Filtration and Renin Release

    Författare :Johan Sällström; Erik Persson; Peter Hansell; Jürgen Schnermann; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : The juxtaglomerular apparatus (JGA) is a control unit of the kidney, that regulates glomerular filtration rate (GFR) and renin release, and hence extracellular volume and blood pressure. The tubuloglomerular feedback (TGF) mechanism is a negative feedback loop that regulates GFR. LÄS MER