Sökning: "Alice Ghidini"

Hittade 1 avhandling innehållade orden Alice Ghidini.

1. 1. Mimicking the action of ribonucleases : studies on RNase A and design of PNA based artificial enzymes

   Författare :Alice Ghidini; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : A 3’-deoxy-3’-C-methylenephosphonate modified diribonucleotide is highly resistant to degradation by spleen phosphodiesterase and not cleaved at all by snake venom phosphodiesterase. Despite that both the vicinal 2-hydroxy nucleophile and the 5’-oxyanion leaving group are intact, the 3’-methylenephosponate RNA modification is also highly resistant towards the action of RNase A. LÄS MER