Sökning: "Patient Specific"

Visar resultat 36 - 40 av 1415 avhandlingar innehållade orden Patient Specific.

1. 36. Exploring Patient-Specific Cell Replacement Therapy for Parkinson's Disease

   Författare :Shelby Shrigley; Utvecklings- och regenerativ neurobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dopaminergic neurons; Parkinson s disease; cell replacement therapy; cellular reprogramming; alpha-synuclein;

   Sammanfattning : Parkinson’s disease (PD) affects over six million people worldwide and is characterised by the progressive loss of dopaminergic (DA) neurons in the substantia nigra, accumulation of pathological alpha-synuclein (αSyn), and inflammation in the brain. This leads to motor impairments including rigidity, akinesia, bradykinesia, resting tremor, and postural instability. LÄS MER

3. 37. Using patient-derived cell models to investigate the role of misfolded SOD1 in ALS

   Författare :Elin Forsgren; Jonathan Gilthorpe; Stefan Marklund; Peter Andersen; Thomas Brännström; Ulrika Nordström; Séverine Boillée; Umeå universitet; []
   Nyckelord :ALS; SOD1; patient-derived models; induced pluripotent stem cells; motor neurons; astrocytes; 20S proteasome low oxygen tension; misfolded SOD1; Neurology; neurologi;

   Sammanfattning : Protein misfolding and aggregation underlie several neurodegenerative proteinopathies including amyotrophic lateral sclerosis (ALS). Superoxide dismutase 1 (SOD1) was the first gene found to be associated with familial ALS. LÄS MER

4. 38. Patient-Specific Finite Element Modeling of the Blood Flow in the Left Ventricle of a Human Heart

   Författare :Jeannette Hiromi Spühler; Johan Hoffman; Johan Jansson; Mariano Vazquez; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Finite element method; Arbitrary Lagrangian-Eulerian method; Fluid-Structure interaction; Contact model; parallel algorithm; blood flow; left ventricle; aortic valves; patient-specific heart model;

   Sammanfattning : Heart disease is the leading cause of death in the world. Therefore, numerous studies are undertaken to identify indicators which can be applied to discover cardiac dysfunctions at an early age. LÄS MER

5. 39. SOD1 misfolding and aggregation in ALS : in the light of conformation-specific antibodies

   Författare :Manuela Lehmann; Jonathan D. Gilthorpe; Stefan L. Marklund; Thomas Brännström; Ulrika Nordström; Elizabeth Fisher; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS; antibodies; SOD1; disordered SOD1; patient-derived models; low oxygen tension; Immunotherapy;

   Sammanfattning : Mutations in the superoxide dismutase 1 (SOD1) gene are linked to the progressive neurodegenerative disease amyotrophic lateral sclerosis (ALS). ALS-associated mutations affect the stability of the SOD1 protein and promote its unfolding. As a consequence, disordered SOD1 species can misfold and accumulate into insoluble aggregates. LÄS MER

7. 40. Learning from patient injury claims

   Författare :Karin Pukk Härenstam; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Background and aim: The Institute of Medicine report, To err is human, heightened attention to safety and quality performance in healthcare. This has led to demands on healthcare systems to collect data on safety and quality performance. LÄS MER