Sökning: "PDGFB"

Visar resultat 1 - 5 av 22 avhandlingar innehållade ordet PDGFB.

  1. 1. The role of PDGF-B in brain blood vessels

    Författare :Khayrun Nahar; Christer Betsholtz; Jean-Baptiste Demoulin; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; PFBC; PDGFB; PDGFRB; Brain vasculature; Mural cells;

    Sammanfattning : The development of blood vessels is dependent on several molecular cues to form properly. A functional PDGF-B/PDGFR-b signaling is paramount for the investment of mural cells, that provide with support, to the developing vasculature. LÄS MER

  3. 2. Platelets – Multifaceted players in tumor progression and vascular function

    Författare :Yanyu Zhang; Anna-Karin Olsson; Gertraud Orend; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Tumor; Platelet; HRG; PDGFB; TBK1; NETs; Angiogenesis; EMT; Metastasis; Medicinsk vetenskap; Medical Science; Oncology; Onkologi; Biologi med inriktning mot molekylär cellbiologi; Biology with specialization in Molecular Cell Biology;

    Sammanfattning : Platelets play a crucial role for blood hemostasis, the process that prevents bleeding. In addition, platelets have been demonstrated to promote cancer progression and cancer related complications like metastasis and thrombosis. LÄS MER

  4. 3. PDGFB and P53 in brain tumorigenesis

    Författare :Sanna-Maria Hede; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Glioblastoma is the most common, and malignant form of brain tumor. It is characterized by a rapid growth and diffuse spread to surrounding brain tissue. The cell of origin is still not known, but experimental data suggest an origin from a glial precursor or neural stem cell. LÄS MER

  5. 4. The role of PDGFB in dermatofibrosarcoma protuberans and giant cell fibroblastoma

    Författare :Kevin P O'Brien; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Dermatofibrosarcoma protuberans; giant cell fibroblastoma; translocation; FISH; translocation breakpoint; fusion gene; oncogene; Platelet derived growth factor B-chain; collagen type I alpha 1; tumor formation; autocrine stimulation;

    Sammanfattning : Dermatofibrosarcoma protuberans (DFSP) and giant cell fibroblastoma (GCF) are rare invasive tumors of the dermis. GCF is considered the juvenile form of DFSP. Both DFSP and GCF are characterized by the presence of chromosomal aberrations involving chromosomes 17 and 22. LÄS MER

  7. 5. Role of platelet-derived growth factor B in cholesterol and glucose metabolism

    Författare :Tian Li; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Platelet-derived growth factor (PDGFB) is a critical molecule for recruiting pericytes. Due to the fundamental role of the pericytes in angiogenesis and vascular stability, PDGFB knockout mice die perinatally from severe hemorrhage and edema. LÄS MER