Sökning: "Nuclear pore complex"

Visar resultat 6 - 10 av 35 avhandlingar innehållade orden Nuclear pore complex.

  1. 6. Imaging the molecular pathways of neurodegeneration : New pathologies of SCA7

    Författare :Frida Niss; Anna-Lena Ström; Einar Hallberg; Georg Auberger; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurodegeneration; SCA7; Polyglutamine diseases; RNA binding proteins; Aggregation; Stress granules; Chromatin organization; Quantitative image analysis; Nuclear envelope; Nuclear pore complex; Nucleocytoplasmic transport; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Spinocerebellar Ataxia type 7 (SCA7) is a genetic neurodegenerative disease with lethal outcome that affects the cerebellum and retina of patients. This thesis focuses on characterising molecular pathological pathways that cause toxicity and cell death in SCA7. LÄS MER

  3. 7. Intracellular sorting of an integral membrane protein from the nuclear pore complex

    Författare :Henrik Söderqvist; Howard J Worman; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biokemi; Biochemistry;

    Sammanfattning : .... LÄS MER

  4. 8. Multifaceted roles of the transmembrane nuclear envelope protein, Samp1

    Författare :Mohammed Hakim Jaffer Ali; Einar Hallberg; Giovanna Lattanzi; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Nuclear envelope; transmembrane protein interaction studies; cell differentiation; stem cells; myopathies; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : The eukaryotic nuclear envelope (NE), separates the nucleoplasm from cytoplasm and is made up of two concentric lipid membranes, the outer and the inner nuclear membranes (ONM and INM), the nuclear pore complexes (NPCs) and an underlying filamentous nuclear lamina. The INM contains hundreds of unique transmembrane proteins of which only a handful have been characterized. LÄS MER

  5. 9. Molecular and ultrastructural analysis of Tpr, a nuclear pore complex-attached coiled-coil protein

    Författare :Manuela Hase; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Anchored in the nuclear envelope, nuclear pore complexes (NPCs) are large multiprotein complexes which serve as the gateway for nucleocytoplasmic transport. In vertebrates, a 267kDa protein termed Tpr has been localized to the nucleoplasmic side of the NPCs. The function of Tpr has remained largely elusive. LÄS MER

  7. 10. Studies of actinides in a superanoxic fjord

    Författare :Per Roos; Lund Medicinsk strålningsfysik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Geology; colloids.; TIMS; pore water; remobilisation; sediments; ultrafiltration; uranium; thorium; americium; plutonium; Anoxic; Framvaren; fjord; physical geography; Geologi; fysisk geografi;

    Sammanfattning : Water column and sediment profiles of plutonium, americium, thorium and uranium have been obtained in the superanoxic Framvaren fjord, southern Norway. The concentrations of bomb test fallout Pu, Am as well as 'dissolved' Th in the bottom water are the highest recorded in the marine environment. LÄS MER