Avancerad sökning

Hittade 2 avhandlingar som matchar ovanstående sökkriterier.

1. 1. The Path to Destruction : Understanding the mechanism and regulation of proteasomal degradation

   Författare :Anne Beskow; Patrick Young; Ylva Engström; Bernat Crosas; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Proteasome; ubiquitin; p97; Cnc-C; transcription factors; Nrf1; Nrf2; Molecular Biology; molekylärbiologi;

   Sammanfattning : A majority of intracellular proteins are degraded by the ubiquitin proteasome system (UPS). In this thesis, both the mechanism of the degradation and the regulation of UPS have been investigated. The importance of the p97 ATPase for proteasomal degradation of cytosolic substrates was examined. LÄS MER

3. 2. Spinal and bulbar muscular atrophy : new insights into the disease mechanism and prospects for pharmacological therapy

   Författare :Laura C Bott; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Expansion of a polyglutamine-encoding trinucleotide CAG repeat in the androgen receptor (AR) gene causes spinal and bulbar muscular atrophy (SBMA, or Kennedy’s disease). SBMA is an adult-onset disease characterized by progressive muscle weakness and atrophy due to the degeneration of lower motor neurons in the brainstem and spinal cord. LÄS MER