Sökning: "Laura C Bott"

Hittade 1 avhandling innehållade orden Laura C Bott.

1. 1. Spinal and bulbar muscular atrophy : new insights into the disease mechanism and prospects for pharmacological therapy

   Författare :Laura C Bott; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Expansion of a polyglutamine-encoding trinucleotide CAG repeat in the androgen receptor (AR) gene causes spinal and bulbar muscular atrophy (SBMA, or Kennedy’s disease). SBMA is an adult-onset disease characterized by progressive muscle weakness and atrophy due to the degeneration of lower motor neurons in the brainstem and spinal cord. LÄS MER