Sökning: "Multiple endocrine neoplasia type 1"

Visar resultat 6 - 10 av 22 avhandlingar innehållade orden Multiple endocrine neoplasia type 1.

  1. 6. On the diagnosis of primary hyperparathyroidism : with special reference to the syndrome of multiple endocrine neoplasia type 1 (MEN-1)

    Författare :Lars Benson; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  3. 7. Molecular studies of endocrine tumors : Insights from genetics and epigenetics

    Författare :Samuel Backman; Per Hellman; Peter Stålberg; Olov Norlén; Robert Bränström; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroendocrine tumors; Carcinoid; Pheochromocytoma; Aldosterone; Cancer; MEN1; Multiple endocrine neoplasia; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Endocrine tumors may be benign or malignant and may occur in any of the hormone producing tissues. They share several biological characteristics, including a low mutation-burden, and may co-occur in several hereditary tumor syndromes. The aim of this thesis was to identify genetic and epigenetic aberrations in endocrine tumors. LÄS MER

  4. 8. From gene mutation to gene expression : studies on multiple endocrine neoplasia type 1 and vascular endothelial growth factors

    Författare :Emma Tham; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Multiple endocrine neoplasia type 1; mutation detection; Vascular Endothelial Growth Factors; recombinant protein; dilated cardiomyopathy; multiple sclerosis;

    Sammanfattning : Multiple Endocrine Neoplasia type 1, MEN1, is an inherited cancer syndrome whose gene was localised to chromosome 11q13 in 1988. A number of !candidate genes were characterised before the MEN1 gene was cloned in 1997. DNA sequencing of MEN1 to search for mutations in patients is used as a complement to clinical diagnosis. LÄS MER

  5. 9. Isolation and characterization of genes within the region for multiple endocrine neoplasia type 1 on chromosome 11q13

    Författare :Jacob Lagercrantz; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Multiple Endocrine Neoplasia type 1 MEN1 ; Chromosome 11q13; Phospholipase C Beta 3 gene PLCB3 ; Phospholipase C Beta 3 Neighbouring Gene PNG ; Vascular Endothelial Growth Factor VEGF ; VEGF Related Factor gene VRF .;

    Sammanfattning : This thesis summarizes the investigations of three genes isolated from the locus for multiple endocrine neoplasia type 1 (MEN1) within the chromosomal region 11q13. As a common strategy for all three genes, the cDNA was sequenced, the genomic structure characterized, and the expression pattern analyzed by Northern blotting on human tissues and by in situ RNA hybridization on slides from rodent embryos. LÄS MER

  7. 10. Pancreatic Endocrine Tumors and GIST - Clinical Markers, Epidemiology and Treatment

    Författare :Sara Ekeblad; Britt Skogseid; Peter Stålberg; Barbro Eriksson; Rajesh Thakker; Uppsala universitet; []
    Nyckelord :Medicine; Pancreatic endocrine tumor; Gastrointestinal stromal tumor; Neuroendocrine; Multiple endocrine neoplasia type 1; Prognostic factors; Temozolomide; TNM staging; O6-methylguanine DNA methyltransferase; Growth hormone secretagogue receptor; Ghrelin; Medicin;

    Sammanfattning : Pancreatic endocrine tumors and gastrointestinal stromal tumors are rare. Evidence regarding prognostic factors, and in the former also treatment, is scarce. We evaluated the survival and prognostic factors in a consecutive series of 324 patients with pancreatic endocrine tumors treated at a single institution. LÄS MER