Sökning: "Temozolomide"

Visar resultat 1 - 5 av 23 avhandlingar innehållade ordet Temozolomide.

1. 1. Pancreatic Endocrine Tumors and GIST - Clinical Markers, Epidemiology and Treatment

   Författare :Sara Ekeblad; Britt Skogseid; Peter Stålberg; Barbro Eriksson; Rajesh Thakker; Uppsala universitet; []
   Nyckelord :Medicine; Pancreatic endocrine tumor; Gastrointestinal stromal tumor; Neuroendocrine; Multiple endocrine neoplasia type 1; Prognostic factors; Temozolomide; TNM staging; O6-methylguanine DNA methyltransferase; Growth hormone secretagogue receptor; Ghrelin; Medicin;

   Sammanfattning : Pancreatic endocrine tumors and gastrointestinal stromal tumors are rare. Evidence regarding prognostic factors, and in the former also treatment, is scarce. We evaluated the survival and prognostic factors in a consecutive series of 324 patients with pancreatic endocrine tumors treated at a single institution. LÄS MER

3. 2. Combined chemotherapy and immunotherapy against experimental malignant brain tumors

   Författare :Sara Fritzell; Neurokirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cisplatin; Glioma; GM-CSF; IFN-gamma; IL-7; Immunotherapy; Intratumoral chemotherapy; Temozolomide;

   Sammanfattning : Glioblastoma multiforme (GBM) is the most common and aggressive primary malignant brain tumor in adults. Despite standard treatment including surgery, radiotherapy and temozolomide (TMZ)-based chemotherapy, the prognosis for GBM patients is dismal, and there is a need for novel treatments. LÄS MER

4. 3. From Genes to Therapy : Modeling and Novel Therapeutic Strategies for Brain Tumors

   Författare :Matko Čančer; Fredrik Swartling; Lene Uhrbom; Suzanne J. Baker; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medulloblastoma; Glioblastoma; MYCN; PDGF; Cancer Therapy; BET bromodomains; Temozolomide; Medicinsk vetenskap; Medical Science; Oncology; Onkologi;

   Sammanfattning : Medulloblastoma is the most common malignant pediatric brain tumor and is molecularly divided into four subgroups – WNT, SHH, Group 3 and Group 4. Two thirds of medulloblastoma patients survive, but survivors often suffer from severe, lifelong side-effects. The MYCN oncogene is deregulated in many medulloblastoma patients. LÄS MER

5. 4. Experimental therapies of malignant glioma : with emphasis on angiogenesis inhibition

   Författare :Maria Sandström; Roger Henriksson; Mikael Johansson; Anja Smits; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioma; angiogenesis; VEGF; tyrosinekinaseinhibitor; ZD6474; plasminogenactivator; tPA; uPA; proteomics; Oncology; Onkologi;

   Sammanfattning : Malignant glioma consists of a group of diseases where the localisation and the nature of the disease makes treatment an extreme challenge. Two important biological features of malignant glioma cells are their infiltrative growth and their ability to induce angiogenesis. LÄS MER

7. 5. Epigenetics of paediatric glioma stem cells; focusing on exosomes, miRNAs and DNA methylation

   Författare :Ágota Tüzesi; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epigenetics; microRNA; DNA methylation; exosomes; glioblastoma; paediatric; glioma stem cells; neural stem cells; TMZ response;

   Sammanfattning : Tumours in the central nervous system are accountable for the majority of cancer-related deaths in children. Glioblastoma multiforme, one of the deadliest of the central nervous system tumours, is partly driven by glioma stem cells. The generation and maintenance of these cells is orchestrated by complex genetic and epigenetic mechanisms. LÄS MER