Sökning: "Chromosome 11q13"
Visar resultat 1 - 5 av 21 avhandlingar innehållade orden Chromosome 11q13.
1. Isolation and characterization of genes within the region for multiple endocrine neoplasia type 1 on chromosome 11q13
Sammanfattning : This thesis summarizes the investigations of three genes isolated from the locus for multiple endocrine neoplasia type 1 (MEN1) within the chromosomal region 11q13. As a common strategy for all three genes, the cDNA was sequenced, the genomic structure characterized, and the expression pattern analyzed by Northern blotting on human tissues and by in situ RNA hybridization on slides from rodent embryos. LÄS MER
2. Endocrine tumour development : with special focus on chromosome arms 1p and 11q
Sammanfattning : The overall goal of this thesis has been to characterise the involvement of chromosome arms 1p and 11 q in the development of endocrine tumours. The MEN1 gene was analysed as a candidate tumour suppressor gene by screening for mutations in follicular thyroid tumours, malignant melanomas, pheochromocytomas, and abdominal paragangliomas. LÄS MER
3. Prognostic factors in squamous cell carcinoma of the head and neck, with emphasis on 11q13 rearrangements and cyclin D1 overexpression
Sammanfattning : At present, clinical outcome or response to therapy can not be fully predicted in individual cases of squamous cell carcinoma of the head and neck (SCCHN). The overall aim of the present studies was to investigate potential prognostic factors, more closely related to the malignant progression of a tumor than the established markers, such as the TNM-classification system. LÄS MER
4. Localization and characterization of genes involved in parathyroid tumor development
Sammanfattning : The overall goal of this thesis has been to identify new genes and characterize them regarding the involvement in parathyroid tumor development. The parathyroid glands are responsible for the control of calcium homeostasis. Parathyroid tumors usually have a benign growth pattern, with less than 1% of the tumors being malignant. LÄS MER
5. Characterization of candidate disease genes from human chromosomes 11g13 and 22q
Sammanfattning : Two regions of the human genome, 11q13 and 22q, have been shown to harbor numerous disease-related genes, among them tumor suppressor genes (TSGs). The aim of this project was to construct transcription maps within these chromosomal segments, and thus provide a basis for further analysis of some of the genes for their involvement in disease-related processes. LÄS MER