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Visar resultat 1 - 5 av 17 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Optimizing Exposome-wide Assessments in Cardiometabolic Risk

   Författare :Hugo Pomares-Millan; Genetisk och molekylär epidemiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lifestyle; Nutritional epidemiology; Cardiometabolic risk; Prediabetes; cardiovascular disease CVD ; Type 2 diabetes T2D ; Machine learning; causal inference; Mediation analysis; Mendelian randomization;

   Sammanfattning : This thesis is focused on cardiovascular disease (CVD) and type 2 diabetes mellitus (T2D), two concomitant conditions that appear with growing concern. In our work, we aim to improve the identification of individuals at-risk of cardiometabolic disease through the characterization of complex environmental exposures (i.e. LÄS MER

3. 2. Metabolic factors and bladder cancer risk and mortality. Studies to approach causal associations and interactions with smoking and genetic variants

   Författare :Stanley Teleka; Registerbaserad epidemiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bladder cancer; metabolic factors; Association; Interaction; Blood pressure; BMI; statistical analysis; Mendelian Randomization Analysis;

   Sammanfattning : Urothelial bladder cancer (BC) is one of the most common cancers in developed countries. It has one of the highest recurrence rates among solid tumors, resulting in regular treatment and follow-up, making it one of the most expensive cancers to treat, and a significant public health burden. LÄS MER

4. 3. Interplay between genetics and environment in obesity

   Författare :Dmitry Shungin; Paul W Franks; Eivind Hovig; Umeå universitet; []
   Nyckelord :obesity; GWAS; gene-environment interactions; waist-hip ratio; body mass index; periodontitis; Mendelian randomization; heterogeneity of variance;

   Sammanfattning : Background. Being one of the largest current global health problems, obesity is a result of interplay between genetic and environmental factors. LÄS MER

5. 4. Insulin Resistance : Causes, biomarkers and consequences

   Författare :Christoph Nowak; Tove Fall; Erik Ingelsson; Johan Sundström; Rachel Freathy; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; insulin resistance; diabetes; insulin secretion; cardiovascular; mendelian randomization; proteomics; metabolomics; genomics; molecular epidemiology; complex disease; risk prediction; coronary heart disease; stroke; hyperglycemia;

   Sammanfattning : The worldwide increasing number of persons affected by largely preventable diseases like diabetes demands better prevention and treatment. Insulin is required for effective utilisation of circulating nutrients. LÄS MER

7. 5. Modifiable risk factors, blood proteins, and venous thromboembolism

   Författare :Shuai Yuan; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Venous thromboembolism (VTE) refers to blood clots in the veins, which is an underappreciated vascular disease that can cause disability and mortality. Although some triggers for VTE (e.g. LÄS MER