Sökning: "MHCII"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet MHCII.

  1. 1. Immunogenetics of Parkinson's disease: Translational studies from rodents to humans

    Författare :Itzia Jimenez; Translationell Neurogenetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; genetics; inflammation; α-synuclein; dopaminergic neurons; MHCII; Mhc2ta; Vra4; PFFs; microglia;

    Sammanfattning : Parkinson's disease (PD) is a complex neurodegenerative disease, characterized by a progressive lossof dopaminergic neurons (DN) in the substantia nigra (SN) that innervate the striatum (ST) and pathologicalaccumulation of alpha-synuclein (αsyn) protein in aggregates called Lewy bodies (LB) and Lewy neurites(LN). As a complex disease, PD presents a genetically heterogeneous origin. LÄS MER

  3. 2. Functional and genetic analyses of the MHC and its impact on autoimmunity in the rat

    Författare :Jonatan Tuncel; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The major histocompatibility complex (MHC) is an allele-rich and exceptionally gene dense region on human chromosome 6. Over 40% of the genes in this region have immune-related functions, including genes encoding MHCI and MHCII molecules. These molecules, which are found in nearly all vertebrates, present antigenic peptides to CD4 and CD8 T cells. LÄS MER

  4. 3. Oral tolerance mechanisms and the role of the microbiota

    Författare :Sofia M Östman; Göteborgs universitet; []
    Nyckelord :;

    Sammanfattning : The hygiene hypothesis state that microbial stimulation is necessary to fully activate and mature the immune system and to sustain tolerance mechanisms. Oral tolerance maintains immune homeostasis in the gut and prevents adverse reactions towards the comensal flora and Ags from the food and thus protects from development of allergies and inflammatory bowel diseases (IBD). LÄS MER

  5. 4. The role of glial cells in alpha-synuclein pathology : Focus on degradation, cell-to-cell propagation and inflammation

    Författare :Jinar Rostami; Anna Erlandsson; Martin Ingelsson; Joakim Bergström; Michael Heneka; Uppsala universitet; []
    Nyckelord :Parkinson’s disease; alpha-synuclein; amyloid-beta; astrocytes; microglia; tunneling nanotubes; antigen presentation; T cells; glial crosstalk; degradation; KYP-2407; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Growing evidence emphasizes the role of astrocytes and microglia in Parkinson’s disease (PD) and Alzheimer’s disease (AD). Yet, little is known about their impact on specific disease processes and if their involvement is beneficial or detrimental. LÄS MER

  7. 5. Dangerous Proteins and Where to Find Them- Structural and functional studies of bacterial and viral proteins interacting with human immune receptors in health and disease

    Författare :Sibel Uzuncayir; Medicinsk strukturbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteins; immunology; structural biology;

    Sammanfattning : Bacteria and viruses are threats to human that evolved strategies to bypass the immune system and can cause massive damage. Understanding these strategies and elucidating pathogen interacting partners within the human immune system will pave the way for discovery of new medicines and increase human well-being. LÄS MER