Sökning: "Nucleoside analogue"

Visar resultat 1 - 5 av 29 avhandlingar innehållade orden Nucleoside analogue.

  1. 1. Structural Studies of Human 5'-Nucleotidases

    Författare :Karin Walldén; Pär Nordlund; Norbert Sträter; Stockholms universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Nucleotidases; nucleotide; nucleoside; nucleoside analogue; Structural biochemistry; Strukturbiokemi; biokemi; Biochemistry;

    Sammanfattning : 5’-Nucleotidases (5’NTs) are catabolic enzymes of the nucleotide metabolism. They catalyze dephosphorylation of deoxyribo- and ribonucleoside monophosphates and constitute an important control point in the regulation of intracellular nucleotide pools for the maintenance of correct DNA and RNA synthesis. LÄS MER

  3. 2. Pharmacology and resistance mechanisms of nucleoside analogues and topoisomerase II interactive agents : studies on human leukemia cells with a focus on cross-resistance

    Författare :Kourosh Lotfi; Rolf Larsson; Linköpings universitet; []
    Nyckelord :Nucleoside analogue; cross-resistance; multidrug resistance; deoxycytidine kinase; leukemia; anthracyclines; P-glycoprotein; MEDICINE; MEDICIN;

    Sammanfattning : The purpose of this thesis was to elucidate mechanisms of action and resistance of clinically relevant nucleoside analogues and topoisomerase interactive agents in human leukemia cell lines and leukernia cells isolated from peripheral blood of leukemia patients. Interactions and cross-resistance patterns of these different cytotoxic drug families were also studied since these drugs are usually administrated in combination in the clinic. LÄS MER

  4. 3. Structure determination of Methanocaldococcus jannaschii nucleoside kinase

    Författare :Linda Arnfors; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Methanocaldococcus jannaschii; Archaea; hyperthermophile; nucleoside kinase; ribokinase family; X-ray crystallography; differential scanning calorimetry; thermal stability;

    Sammanfattning : All organisms can be divided into the tree kingdoms of life: Archaea, Bacteria and Eukarya. Archaeal organisms are often found to exhibit, compared to human perspectives, extreme environments, such as high temperature, high salt and acidic habitats. Many archaeal species are hyperthermophiles, i.e. LÄS MER

  5. 4. Distribution of antiviral nucleoside analogues into brain and skin

    Författare :Natalia Borg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The aim of this thesis was to study physiological and physico-chemical factors influencing the pharmacokinetics and distribution over the blood-brain barrier of antiviral nucleoside analogues in the rat, and to study the distribution to the human skin in vivo of an anti-herpetic nucleoside analogue. Microdialysis was used to sample the free (unbound) extracellular concentration of the nucleoside analogues from the brain tissue, muscle and blood in the rat and from the dermis of healthy human volunteers. LÄS MER

  7. 5. Resistance mechanisms for nucleoside analogues : with focus on metabolism and apoptosis

    Författare :Emma Månsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The aim of the thesis was to elucidate the mechanisms underlying resistance to nucleoside analogues used in the treatment of leukemias, with focus on cellular metabolism and induction of apoptosis. Cladribine (CdA), Clofarabine (CAFdA), Fludarabine (Fara-A) and Nelarabine (Ara-G) are nucleoside analogues with activity against various types of leukemias. LÄS MER