Sökning: "Lipid biosynthesis"

Visar resultat 1 - 5 av 78 avhandlingar innehållade orden Lipid biosynthesis.

1. 1. Understanding Heparan Sulfate Biosynthesis and Functional Implications of Heparanase

   Författare :Tianyi Song; Dorothe Spillmann; Cathrine Merry; Uppsala universitet; []
   Nyckelord :Heparan sulfate; biosynthesis; heparanase; lipid metabolism; cancer; cell adhesion; apoptosis.; Molekylär medicin;

   Sammanfattning : Heparan sulfate (HS) proteoglycans are present on the plasma membrane of all animal cells studied so far and are a major component of extracellular matrices. Heparanase is an endo-ß-glucuronidase that cleaves HS chains at internally located ß-glucuronidic linkages1. LÄS MER

3. 2. Lipid Turnover in Plants and Yeast, A Study of Storage Lipid Synthesis and Lipid-Based Signalling in Plants and Yeast

   Författare :Maria Gustavsson; Biokemi och Strukturbiologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Växtbiokemi; Plant biochemistry; turnover; plasma membrane; plant; PLA2; biosynthesis; S. cerevisiae; triacylglycerol;

   Sammanfattning : In this thesis, lipid biosynthesis is discussed focussing on the genes and enzymes involved in the final step of storage lipid synthesis, on the enzyme phospholipase A2, and on cell membrane lipid homeostasis. The investigation of lipid metabolism revealed that in Saccharomyces cerevisiae, there are four genes that are essential for the final step of storage lipid biosynthesis; ARE1, ARE2, DGA1, and LRO1. LÄS MER

4. 3. Structural and biochemical insights into biosynthesis and degradation of N-glycans

   Författare :Tom Reichenbach; Christina Divne; David Drew; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; N-glycan; biosynthesis; degradation; glycosyltransferase; glycoside hydrolase; biofuel; enzyme; membrane protein; Bioteknologi; Biotechnology;

   Sammanfattning : Carbohydrates are a primary energy source for all living organisms, but importantly, they also participate in a number of life-sustaining biological processes, e.g. cell signaling and cell-wall synthesis. The first part of the thesis examines glycosyltransferases that play a crucial role in the biosynthesis of N-glycans. LÄS MER

5. 4. The assembly of cytosolic lipid droplets and its effect on insulin sensitivity

   Författare :Pontus Boström; Göteborgs universitet; []
   Nyckelord :diabetes; lipid metabolism; insulin resistance; lipid droplets; ADFP; SNARE;

   Sammanfattning : Accumulation of neutral lipids, in particular triglycerides, in non-adipocytes is highly related to the development of insulin resistance and its consequences, type-2 diabetes and cardiovascular diseases. The accumulation of triglycerides occurs in so-called lipid droplets in the cytosol. LÄS MER

7. 5. Systems Biology of Yeast Lipid Metabolism

   Författare :Pramote Chumnanpuen; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Transcriptome; Integrated analysis; Lipidome.; Inositol-choline; Opi1; Yeast lipid metabolism; high throughput techniques; Ino4; TORC1; Snf1; Ino2;

   Sammanfattning : Lipid metabolism plays an important role in the development of many different life-style related diseases, such as type 2 diabetes and atherosclerosis, and understanding the molecular mechanisms behind regulation of lipid biosynthesis and degradation may lead to development of new therapies. In this project we undertook a global study of lipid metabolism in the eukaryotic model organism Saccharomyces cerevisiae. LÄS MER