Visar resultat 1 - 5 av 10 avhandlingar innehållade ordet N-glycan.
Sammanfattning : Carbohydrates are a primary energy source for all living organisms, but importantly, they also participate in a number of life-sustaining biological processes, e.g. cell signaling and cell-wall synthesis. The first part of the thesis examines glycosyltransferases that play a crucial role in the biosynthesis of N-glycans. LÄS MER
Sammanfattning : The influences of posttranslational modifications on the functions of the versatile serpin protein C inhibitor (PCI) were studied. PCI is a serine protease inhibitor that is expressed in many tissues and secreted to various fluids in human, including blood plasma, seminal plasma, and urine. LÄS MER
Sammanfattning : The first part of this thesis describes investigations of the conformations of six N-linked pseudodisaccharides (Paper I), which were synthesized as glycosidase inhibitor candidates, and 10 β-D-xylopyranoside derivatives bearing hydrophobic aglycons (Paper II), by NMR spectroscopic methods. In paper I the ring conformations of 2- and 3-amino-α-D-altropyranosides, and ω torsions of altrosides, glucosides and mannosides were described, in neutral and protonated states. LÄS MER
Sammanfattning : Human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) are the etiological agents of AIDS in humans. The viral envelope glycoproteins gp120 and gp41 mediate the early virus-cell interaction of HIV with the target cells. LÄS MER
Sammanfattning : The enzymatic degradation of wood polysaccharides such as cellulose and hemicellulose is an important process in nature. In addition, cellulases and hemicellulases can be used in industrial applications. Fuel ethanol can potentially be produced from wood by enzymatic hydrolysis of cellulose followed by yeast fermentation of the formed sugars. LÄS MER