Sökning: "Kynurenine pathway"

Visar resultat 1 - 5 av 26 avhandlingar innehållade orden Kynurenine pathway.

  1. 1. Inflammatory activation of the kynurenine pathway : studies with lipopolysaccharides

    Författare :Anthi Faka Schulte; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neuroinflammation is increasingly recognised as playing an important role in several major psychiatric disorders. The mechanisms by which neuroinflammation influences neurotransmitter systems have for long been unknown. LÄS MER

  3. 2. Dysregulation of the kynurenine pathway in psychotic disorders : immunological aspects

    Författare :Magdalena Kegel; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Kynurenic acid (KYNA), a metabolite of the kynurenine pathway, is emerging as a key factor in the development of psychotic disorders. Increased levels of KYNA are found in the brain and cerebrospinal fluid (CSF) of patients with schizophrenia and bipolar disorder, and are associated to psychotic symptoms. LÄS MER

  4. 3. Bridging immune activation with the kynurenine pathway : implications for psychosis

    Författare :Markus Larsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Kynurenic acid (KYNA), an endogenous N-Methyl-D-aspartic acid receptor (NMDAR) antagonist, is elevated in patients with schizophrenia. In addition, elevated levels of KYNA are associated with activation of the immune system, which also has been implicated in the development and maintenance of psychotic disorders, including schizophrenia. LÄS MER

  5. 4. Inflamed Depression - Origin, Essence, and Remedies

    Författare :Klara Suneson; Lund Psykiatri; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Depression; Inflammation; Omega-3 fatty acids; Kynurenine pathway; Phenotypes; Selective serotonin reuptake inhibitor SSRI ;

    Sammanfattning : .... LÄS MER

  7. 5. Lifestyle, biomarkers and the risk of developing inflammatory bowel disease

    Författare :Lovisa Widbom; Johan Hultdin; Pontus Karling; Kim Ekblom; Kristina Stefansson; Andreas Münch; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inflammatory bowel disease; ulcerative colitis; Crohn s disease; smoking; cotinine; iron deficiency; ferritin; pyridoxal-5-phosphate; kynurenine pathway; Clinical Chemistry; klinisk kemi; invärtesmedicin; Internal Medicine;

    Sammanfattning : Introduction: Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), is a chronic disease causing inflammation in the gut mucosa. The pathogenesis involves alteration in gut microbiota and in the intestinal barrier due to genetic factors, environmental exposure and dysregulation of the immune response. LÄS MER