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1. 1. Nitric oxide production by the intestinal mucosa during hypoperfusion

   Författare :Johan Snygg; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Nitric oxide; nitric oxide synthase; intestinal epithelium; hemorrhagic shock; cardiac tamponade; septic shock; lower body negative pressure; splanchnic circulation; substrate; laser Doppler;

   Sammanfattning : The present thesis is based on the concept that gastrointestinal blood hypoperfusion is a common phenomenon associated with critical illness. Furthermore, the development of the multiple organ dysfunction syndrome (MODS) is proposed to be initiated by gastrointestinal mucosal barrier dysfunction, allowing intestinal luminal contents to penetrate into the tissue and activate a systemic inflammatory response. LÄS MER