Sökning: "In vivo imaging"

Visar resultat 16 - 20 av 393 avhandlingar innehållade orden In vivo imaging.

  1. 16. Imaging the organ of Corti in vitro and in vivo

    Författare :Igor Tomo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Recent developments in imaging techniques, namely confocal laser scanning microscopy, offer new tools in exploration of the structure and function of the inner ear. The optical sectioning property of the confocal microscope enables investigation of living cells deeper within a labeled intact tissue. LÄS MER

  3. 17. In vivo bioluminescence imaging in preclinical trials of genetic vaccines

    Författare :Stefan Petkov; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : DNA immunization is a rapidly developing vaccine platform for infectious diseases, cancer and allergies. The efficiency of DNA vaccination is largely determined by the efficiency of delivery and subsequent expression of genes encoding microbial and tumor antigens or allergens in the cells of vaccine recipients. LÄS MER

  4. 18. In vivo bioluminescence imaging in preclinical trials of genetic vaccines

    Författare :Stefan Petkov; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : DNA immunization is a rapidly developing vaccine platform for cancer, infectious disease, and allergies. The efficiency of DNA vaccination is largely determined by the efficiency of delivery and subsequent expression of the HIV-1 genes in the cells. LÄS MER

  5. 19. Radiolabelled affibody molecules for imaging EGFR expression in tumours

    Författare :Maryam Oroujeni; Vladimir Tolmachev; Martin Behe; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Affibody molecules; ZEGFR:2377; radionuclide molecular imaging; PET; SPECT; labelling chemistry.;

    Sammanfattning : Affibody molecules are promising scaffold-based targeting proteins for radionuclide imaging and cancer therapy. This thesis is based on 5 original research articles (Papers I-V), with the primary focus being placed on the optimization of molecular design of EGFR-binding affibody variants for high contrast imaging of epidermal growth factor receptor (EGFR) expression in tumours. LÄS MER

  7. 20. Endoplasmic Reticulum Dynamic Structural Changes in Neurons: The Fission-Fusion Phenomena

    Författare :Krzysztof Kucharz; Sektion IV; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; fragmentation; fission; endoplasmic reticulum; neurons; FRAP; primary cultures; organotypic slice cultures; in vivo; in situ; calcium; fusion; NMDA receptor; 2-photon microscopy; confocal microscopy;

    Sammanfattning : The endoplasmic reticulum (ER) is crucial for protein synthesis and protein maturation, is involved in cell stress and serves in neurons as the major intracellular Ca2+ store. Neuronal ER forms a continuous network of cisterns and tubules extending from soma to a subset of dendritic spines. LÄS MER