Sökning: "IgH gene expression"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden IgH gene expression.

  1. 1. Expression of Ig genes. Regulation of transcription and production of human antibodies

    Författare :Christina Furebring; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; Bioteknik; Biotechnology; human antibodies; immunoglobulin gene expression; 3 enhancer; serology; transplantation; Immunologi; serologi;

    Sammanfattning : During B lymphocyte development, the transcriptional activity of the IgH locus is subject to spatial and temporal changes. The 3' enhancer (3'E) has been suggested to play an important role in regulation of immunoglobulin gene expression late in B cell development. LÄS MER

  3. 2. Immune reconstitution after allogeneic hematopoietic stem cell transplantation

    Författare :Brigitta Omazic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Immune reconstitution; allogeneic haematopoietic stem cell transplantation; IgH gene expression; TcRVbeta gene expression; B lymphocytes; T lymphocytes; IGF-1 receptor; thyroid hormone receptor.;

    Sammanfattning : After treatment with allogeneic hernatopoietic stem cell transplantation (HSCT) the patient suffers from a deficient immune system for at least 12 months or longer. During this period, the patient is susceptible to infections and if the state of immune deficiency is prolonged there is an increased risk of relapse of the underlying malignancy as well as development of secondary malignancies. LÄS MER

  4. 3. Transcription factors regulating the immunoglobulin heavy chain locus

    Författare :Tove Andersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The immunoglobulin heavy (IgH) chain locus is subject to somatic recombination and changes in gene expression in B lineage cells. Enhancers located in the 3' end of the locus may in part regulate these events. This work aimed at increasing the understanding of the function of one of these elements, the HS1,2 enhancer. LÄS MER

  5. 4. The role of SOXC transcription factors in B-cell development and lymphoid malignancies

    Författare :Martin Lord; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mantle cell lymphoma (MCL) accounts for 5-10% out of all Non-Hodgkin lymphomas (NHLs) and is one of the most aggressive forms of lymphomas with a median survival of less than 5 years. Currently, MCL is considered to be an incurable disease. LÄS MER

  7. 5. The immunoglobulin heavy chain 3ʼ enhancer : coupling of basic-Helix-Loop-Helix proteins to the regulation of enhancer function

    Författare :Velmurugesan Arulampalam; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : During B lymphocyte development, the transcriptional activity of the IgH locus is subject to spatial and temporal changes. One cis-control element, the IgH 3' enhancer, has been implicated in regulating functional events in late B cell development. LÄS MER