Sökning: "Immune reconstitution"

Visar resultat 1 - 5 av 34 avhandlingar innehållade orden Immune reconstitution.

  1. 1. Immune reconstitution after childhood leukemia. Aspects on immunizations and effects of Ara-C on the innate immune system

    Författare :Torben Ek; Göteborgs universitet; []
    Nyckelord :acute lymphoblastic leukemia; immune reconstitution; immunization; antibody; avidity; ara-C; fever; cytokines;

    Sammanfattning : Children with acute lymphoblastic leukemia (ALL) can be cured with cytotoxic chemotherapy, but myelosuppression and immunosuppression are major side effects causing morbidity and even mortality from infections. Vaccinations with diphtheria toxoid (DT), tetanus toxoid (TT) and protein conjugated Haemophilus influenzae type B (Hib) capsular polysaccharide were used to investigate the adaptive immune system in a controlled study of 31 children after treatment for ALL. LÄS MER

  3. 2. Immune reconstitution after allogeneic hematopoietic stem cell transplantation

    Författare :Brigitta Omazic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Immune reconstitution; allogeneic haematopoietic stem cell transplantation; IgH gene expression; TcRVbeta gene expression; B lymphocytes; T lymphocytes; IGF-1 receptor; thyroid hormone receptor.;

    Sammanfattning : After treatment with allogeneic hernatopoietic stem cell transplantation (HSCT) the patient suffers from a deficient immune system for at least 12 months or longer. During this period, the patient is susceptible to infections and if the state of immune deficiency is prolonged there is an increased risk of relapse of the underlying malignancy as well as development of secondary malignancies. LÄS MER

  4. 3. Reconstitution of the B-cell repertoire following allogeneic bone marrow transplantation

    Författare :Ingrid Näsman Björk; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :B cell repertoire allogeneic bone marrow transplantation immune reconstitution immunoglobulin genes serum immunoglobulin;

    Sammanfattning : Allogeneic bone marrow transplantation (BMT) is an established therapy for patients with a variety of haematological malignancies. Patients undergoing BMT often suffer from severe infections that can be partly explained by humoral immune deficiency. LÄS MER

  5. 4. Immune response during hepatitis B virus infection and reconstitution of HBV-specific immunity using T cells redirected against HBV

    Författare :Sarene Koh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hepatitis B is one of the most prevalent viral diseases worldwide and is a major public health concern, particularly in Asia. Of the 350 million people suffering from chronic hepatitis B virus (HBV) infection worldwide, approximately 75% are found in Asia. LÄS MER

  7. 5. Chronic immune activation and lymphocyte apoptosis during HIV-1 infection

    Författare :Nicolas Ruffin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : HIV-1 infected individuals are subject to a chronic immune activation resulting from HIV-1 replication, microbial translocation, and lymphopenia. Despite the great advance of antiretroviral treatment (ART), the immune activation remains associated with poor immune reconstitution during HIV-1 infection. LÄS MER