Sökning: "Histidine"

Visar resultat 16 - 20 av 141 avhandlingar innehållade ordet Histidine.

1. 16. Interaction of Heparan Sulfate with Pro- and Anti-Angiogenic Proteins

   Författare :Maarten Vanwildemeersch; Dorothe Spillmann; Ulf Lindahl; Anders Aspberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; heparan sulfate; angiogenesis; fibroblast growth factors; endostatin; histidine-rich glycoprotein; Biokemi; Biochemistry; Biokemi;

   Sammanfattning : Heparan sulfate (HS) is an unbranched and negatively charged polysaccharide of the glycosaminoglycan family, based on the repeated (GlcNAcα1-4GlcAβ1-4) disaccharide structure. The HS backbone is modified by epimerization and sulfation in various positions. LÄS MER

3. 17. Genetic and epidemiological aspects of implantation defects : Studies on recurrent miscarriage, preeclampsia and oocyte donation

   Författare :Evangelia Elenis; Agneta Skoog Svanberg; Alkistis Skalkidou; Gunilla Sydsjö; Helena Åkerud; Anja Pinborg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Angiogenesis; genetic polymorphism; gestational hypertensive disorders; Histidine-rich glycoprotein; HRG; implantation defect; oocyte donation; placentation; preeclampsia; recurrent miscarriage; SNP.; Obstetrik och gynekologi; Obstetrics and Gynaecology;

   Sammanfattning : Implantation requires complex molecular and cellular events involving coagulation, angiogenesis and immunological processes that need to be well regulated for a pregnancy to establish and progress normally.  The overall aim of this thesis was to study different models associated with atypical angiogenesis, impaired implantation and/or placentation, such as recurrent miscarriage (RM), oocyte donation (OD) and preeclampsia. LÄS MER

4. 18. Pre-eclampsia – Possible to Predict? : A Biochemical and Epidemiological Study of Pre-eclampsia

   Författare :Marie Bolin; Helena Åkerud; Anna-Karin Wikström; Inger Sundström-Poromaa; Karel Marsal; Uppsala universitet; []
   Nyckelord :pre-eclampsia; angiopoietin; histidine-rich glycoprotein; hyperemesis gravidarum; Obstetrik och gynekologi; Obstetrics and Gynaecology;

   Sammanfattning : Pre-eclampsia is a major cause of maternal and perinatal morbidity and mortality worldwide. A predictor of pre-eclampsia would enable intervention, close surveillance and timely delivery, and thereby reduce the negative consequences of the disorder. LÄS MER

5. 19. Molecular and Biological Characteristics of Stroma and Tumor Cells in Colorectal Cancer

   Författare :Jingfang Gao; Xiao-Feng Sun; Richard Palmqvist; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Carcinogenesis; genetic alterations; colorectal cancer CRC ; cysteine-histidine rich protein PINCH ; Inflammatory infiltration; Angiogenesis; lymphangiogenesis; Oncology; Onkologi;

   Sammanfattning : Carcinogenesis is a progressive process involving multiple genetic alterations in tumor cells and complex interactions in the tumor-host microenvironment. To better understand the contribution of molecular alterations in tumor cells and stromal variables to the development of colorectal cancer (CRC) and identify prognostic factors, in this study we examined the clinicopathological and biological significance of stromal variables, including particularly interesting new cysteine-histidine rich protein (PINCH), inflammatory infiltration, angiogenesis and lymphangiogenesis, as well as hRAD50/hMRE11/hNBS1 proteins and hRAD50 mutation in tumor cell in CRC. LÄS MER

7. 20. Development of a novel methodology for the synthesis of oligonucleo-peptide conjugates

   Författare :Simone Zaramella; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Antisense; Oligonucleotide-peptide conjugates; Solid-phase synthesis; Histidine; Protecting groups.;

   Sammanfattning : Peptide-oligonucleotide conjugates constitute a new class of antisense molecules that exhibit improved biological activity over standard oligonucleotide analogues. Currently, these oligomeric bioconjugates are prepared by either solution- or solid-phase techniques. LÄS MER