Sökning: "cysteine-histidine rich protein PINCH"

Hittade 2 avhandlingar innehållade orden cysteine-histidine rich protein PINCH.

  1. 1. Molecular and Biological Characteristics of Stroma and Tumor Cells in Colorectal Cancer

    Författare :Jingfang Gao; Xiao-Feng Sun; Richard Palmqvist; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Carcinogenesis; genetic alterations; colorectal cancer CRC ; cysteine-histidine rich protein PINCH ; Inflammatory infiltration; Angiogenesis; lymphangiogenesis; Oncology; Onkologi;

    Sammanfattning : Carcinogenesis is a progressive process involving multiple genetic alterations in tumor cells and complex interactions in the tumor-host microenvironment. To better understand the contribution of molecular alterations in tumor cells and stromal variables to the development of colorectal cancer (CRC) and identify prognostic factors, in this study we examined the clinicopathological and biological significance of stromal variables, including particularly interesting new cysteine-histidine rich protein (PINCH), inflammatory infiltration, angiogenesis and lymphangiogenesis, as well as hRAD50/hMRE11/hNBS1 proteins and hRAD50 mutation in tumor cell in CRC. LÄS MER

  3. 2. Biological and histological factors as predictors in rectal cancer patients : A study in a clinical trial of preoperative radiotherapy

    Författare :Annica Holmqvist; Xiao-Feng Sun; Gunnar Adell; Jan-Erik Frödin; Östergötlands Läns Landsting; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Onkologi;

    Sammanfattning : With improved surgical techniques and preoperative radiotherapy (RT) the local recurrence rate in rectal cancer patients has been reduced, however the mortality rate is still high and there is a huge variation in the response to preoperative RT in patients with the same tumour stage. To improve patient’s survival, it is of great importance to identify good prognostic and predictive factors that help us to select the best suited patients for preoperative RT in the future. LÄS MER