Sökning: "HSV-1"
Visar resultat 21 - 25 av 33 avhandlingar innehållade ordet HSV-1.
21. On Monomeric and Trimeric dUTPases. Recombinant Expression, Purification, Conformational Properties and Catalytic Characteristics
Sammanfattning : Nucleotide metabolism and replication of nucleic acids are processes of fundamental importance. A crucial enzyme in nucleotide metabolism is dUTPase (E.C. 3. LÄS MER
22. Alphaherpesvirus infections of the central nervous system – Biomarkers, diagnostics and antiviral therapy
Sammanfattning : Abstract Herpesviruses predate the evolution of humans and are globally ubiquitous. Herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), and varicella-zoster virus (VZV) establish latency in neuronal tissue and may cause infections in the central nervous system (CNS). LÄS MER
23. Glycoprotein G of Herpes simplex virus type 2. Antigenicity and genetic variability
Sammanfattning : Herpes simplex virus type 2 (HSV-2) causes genital lesions, meningitis and occasionally, severe neonatal infections. Globally HSV-2 infection is one of the most common sexually transmitted diseases. LÄS MER
24. Strategies to optimize natural killer cell functions in the tumor microenvironment
Sammanfattning : Immune cell-based therapies are currently changing the oncological treatment landscape worldwide. While genetically modified T cells have already been approved for clinical use in few hematological cancers, natural killer (NK) cell-based therapies are employed in early phase clinical trials. LÄS MER
25. Evaluation of the deoxyribonucleoside kinase of Drosophila melanogaster (Dm-dNK) as a suicide gene for treatment of solid tumors
Sammanfattning : Nucleoside kinases from several species are investigated as "suicide genes" for treatment of malignant tumors. The transfer of the gene encoding herpes simplex virus type-1 thymidine kinase (HSV-1 TK) into malignant cells and subsequent treatment with ganciclovir is one of the most commonly studied strategies of suicide gene therapy. LÄS MER