Sökning: "HOXB4"

Hittade 4 avhandlingar innehållade ordet HOXB4.

  1. 1. The Role of HoxB4 in Hematopoiesis

    Författare :Ann Brun; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematologi; extracellulära vätskor; Haematology; extracellular fluids; adenovirus; gene transfer; knock out; HOXB4; HOXB3; homeobox genes; hematopoietic stem cells; Transcription factors; hematopoiesis;

    Sammanfattning : HOXB4 is one of 39 members of the homeobox (HOX) family, a family of transcription factors involved in embryonic development. Several HOX transcription factors, including HOXB4, are highly expressed in hematopoietic stem cells (HSCs) but are downregulated upon differentiation towards more mature progeny cells. LÄS MER

  3. 2. The Role of Hox Transcription Factors in the Regulation of Hematopoiesis

    Författare :Mattias Magnusson; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematologi; extracellulära vätskor; extracellular fluids; Haematology; Hox genes; Knockout; Hematopoietic stem cells; Hematopoiesis; Transcription Factor;

    Sammanfattning : Hematopoiesis is a lifelong, dynamic process, originating from a low number of hematopoietic stem cells (HSCs) residing in the adult bone marrow with the ability to self-renew and generate all blood lineages throughout life. Recent findings have demonstrated that the Homeobox (Hox) transcription factors are important regulators of both normal and malignant hematopoiesis, controlling proliferation, differentiation and self-renewal of hematopoietic cells at different levels of the hematopoietic hierarchy. LÄS MER

  4. 3. Genetic modification and mesodermal differentiation of human embryonic stem cells

    Författare :Christian Unger; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Pluripotent human embryonic stem cells (hESCs) are a resource of great potential, available for research. Their capability to differentiate into any cell of the human body and an unlimited in vitro expansion offers the possibility to study the earliest human development and provides a source of cells for regenerative medicine. LÄS MER

  5. 4. Hox transcription factors in hematopoiesis

    Författare :Jon Mar Björnsson; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular fluids; Hematologi; extracellulära vätskor; Haematology; hematopoies; tet; Hox; cre lox;

    Sammanfattning : Hematopoiesis is a lifelong, dynamic process in which a small number of pluripotent hematopoietic stem cells (HSC) residing in the bone marrow (BM) give rise to billions of mature blood cells of both myeloid and lymphoid origin each day. This enormous capacity of HSC has been utilized in BM transplantations for 4 decades and is also very important for future gene therapy. LÄS MER