Sökning: "cre lox"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden cre lox.

  1. 1. Hox transcription factors in hematopoiesis

    Författare :Jon Mar Björnsson; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular fluids; Hematologi; extracellulära vätskor; Haematology; hematopoies; tet; Hox; cre lox;

    Sammanfattning : Hematopoiesis is a lifelong, dynamic process in which a small number of pluripotent hematopoietic stem cells (HSC) residing in the bone marrow (BM) give rise to billions of mature blood cells of both myeloid and lymphoid origin each day. This enormous capacity of HSC has been utilized in BM transplantations for 4 decades and is also very important for future gene therapy. LÄS MER

  3. 2. Functional Aspects of Peripheral and Spinal Cord Neurons Involved in Itch and Pain

    Författare :Bejan Aresh; Malin Lagerström; Klas Kullander; Martin Schmelz; Uppsala universitet; []
    Nyckelord :mGluR7; anaphylaxis; Grpr; Penk; Pdyn; Cre line; BAC cloning; spinal cord; transgenic line; Medicinsk vetenskap; Medical Science;

    Sammanfattning : We have investigated the role of the metabotropic glutamate receptor 7 (mGluR7) and the gastrin releasing peptide receptor (Grpr) population that are involved at different levels of itch transmission. We found that mGuR7 deficient mice displayed an anaphylaxis-like behavior when provoked with histamine. LÄS MER

  4. 3. Aspects of T cell development contributing to autoimmunity

    Författare :Maria Carlsén; Diabetes - immunovirologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; FTOC; T cell development; Type 1 diabetes; p53; Insulin; NOD; Negative selection; TGF-β; Tolerance; Thymus; Conditional cre lox knock out; Autoimmunity;

    Sammanfattning : Autoimmunity, such as type 1 diabetes (T1D), arises as a result of tolerance breakdown against host tissues, i.e. the β-cells. Central tolerance is established during thymic T cell development and defects in key events during this process could contribute to the pathogenesis of autoimmune diseases. LÄS MER

  5. 4. Signaling Mechanisms in the Neuronal Networks of Pain and Itch

    Författare :Katarzyna Rogoz; Klas Kullander; Malin Lagerström; Stephen McMahon; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mouse genetics; neuronal network; glutamate; sensory neuron; dorsal root ganglion; pain; itch; Neuroscience; Neurovetenskap; Molekylär genetik; Molecular Genetics;

    Sammanfattning : Glutamate is the essential neurotransmitters in pain pathways. The discovery of the vesicular glutamate transporters (VGLUT1-3) has been a fundamental step on the way to describe glutamate-dependent pain pathways. We used the Cre-lox system to construct conditional knockouts with deficient Vglut2 transmission in specific neuronal populations. LÄS MER

  7. 5. Investigating the role of neural stem/progenitor regulators in the context of brain tumor development

    Författare :Isabelle Leefa Chong San; Stamcellscentrum (SCC); []
    Nyckelord :neural stem progenitor cells; regulators; brain tumor; cell of origin; cancer mechanisms;

    Sammanfattning : Adult neural stem/progenitor cells (NSPs) are multipotent and self-renew over an extensive period of time. Transformation events in such cells, such as genetic or epigenetic alterations can result in brain tumors. LÄS MER