Sökning: "hematopoies"

Hittade 5 avhandlingar innehållade ordet hematopoies.

1. 1. Pathways that govern hematopoietic stem cell fate

   Författare :Matilda Billing; Avdelningen för molekylärmedicin och genterapi; []
   Nyckelord :hematopoies; Hematopoietic stem cell; TGF beta; Smad signaling; GATA2; p57;

   Sammanfattning : Hematopoietic stem cells (HSCs) compose a rare population of undifferentiated cells, residing in the bone marrow of adult individuals, ensuring life-long maintenance and replenishment of the blood system. This fantastic achievement is possible owing to two special characteristics of the HSCs: their ability to make copies of themselves (self-renew), and their capacity to differentiate to all lineages of the blood system. LÄS MER

3. 2. Hox transcription factors in hematopoiesis

   Författare :Jon Mar Björnsson; Avdelningen för molekylärmedicin och genterapi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular fluids; Hematologi; extracellulära vätskor; Haematology; hematopoies; tet; Hox; cre lox;

   Sammanfattning : Hematopoiesis is a lifelong, dynamic process in which a small number of pluripotent hematopoietic stem cells (HSC) residing in the bone marrow (BM) give rise to billions of mature blood cells of both myeloid and lymphoid origin each day. This enormous capacity of HSC has been utilized in BM transplantations for 4 decades and is also very important for future gene therapy. LÄS MER

4. 3. Molecular and Functional Dynamics of Hematopoietic Progenitor Cell Fate During Ontogeny

   Författare :Maria Jassinskaja; Proteomisk hematologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hematopoies; developmental hematopoiesis; Proteomics; Leukemia; Mass Spectrometry;

   Sammanfattning : Hematopoietic stem and progenitor cells (HSPCs) in the fetus and the adult possess distinct molecular signatures that regulate cell fate and change their susceptibility to initiation and progression of hematological malignancies, such as leukemia. It is well established that fetal and adult hematopoiesis are functionally distinct processes; however, the underlying molecular mechanisms that govern ontogenic differences in normal and malignant hematopoiesis have thus far been poorly explored on the proteomic level. LÄS MER

5. 4. Laminins and Fibulins in Bone Marrow

   Författare :Yu-Chen Gu; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glucocorticoids; integrin; Immunology; serology; Immunologi; serologi; transplantation; Cytology; oncology; Biokemi; Metabolism; Biochemistry; cancer; onkologi; cancerology; Cytologi; fibulin; laminin; bone marrow;

   Sammanfattning : Development of hematopoietic cells in bone marrow takes place in association with the hematopoietic microenvironment. Extracellular matrix (ECM) molecules and stromal cells in bone marrow provide a structural environment for hematopoietic cells, but they also directly influence proliferation, differentiation and migration of cells by signal transduction mediated by ligand binding to cell surface adhesion receptors. LÄS MER

7. 5. Regulation of hematopoiesis by the Smad signaling pathway

   Författare :Ulrika Blank Savukinas; Avdelningen för molekylärmedicin och genterapi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; retroviral mediated gene expression; conditional knockout; hematopoietic stem cell; hematopoiesis; Transforming growth factor-beta; Smad signaling; Medicin människa och djur ;

   Sammanfattning : Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) of adult individuals and are ultimately responsible for the continuous production of blood cells throughout life. The regulation of HSCs in vivo is tightly regulated by both intrinsic and extrinsic factors. LÄS MER