Sökning: "HLA-E"

Visar resultat 6 - 10 av 16 avhandlingar innehållade ordet HLA-E.

  1. 6. Mechanisms influencing natural killer cell recognition of tumour cells

    Författare :Monika Enqvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Natural killer (NK) cells are part of our innate immune defence against virus-infected and transformed cells. Through a yet undefined mechanism, expression of inhibitory receptors for self-HLA class I molecules endow NK cells with increased functionality. The process leading to gain of function through inhibition is known as NK cell education. LÄS MER

  3. 7. Decoding NK cell receptor specificity : functional and structural studies of MHC class 1 subcomponents

    Författare :Jakob Michaëlsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NK cells; MHC class 1; inhibitory receptors;

    Sammanfattning : Natural Killer (NK) cells are an important part of the innate immune system. They can lyse target cells and secrete immunoregulatory cytokines early during immune responses. They mediate protection against viruses and tumours, and can reject MHC class I mismatched bone marrow grafts. LÄS MER

  4. 8. Study of the psoriasis proteome and analysis of MHC class I expression and function

    Författare :Lina Carlén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Complex disease; psoriasis; proteomics; human leukocyte antigen C HLA-C ; major histocompatibility complex; 2D PAGE; inflammation; skin disease;

    Sammanfattning : Psoriasis is a common inflammatory skin disease affecting approximately 2% of the population in Sweden. Psoriasis displays clinical heterogeneity leading to several different types of manifestations, among them chronic plaque and acute guttate psoriasis. LÄS MER

  5. 9. On the role of Natural Killer cell immunogenetics for the outcome of immunotherapy in acute myeloid leukemia

    Författare :Brwa Ali Hussein; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Natural killer cells; Acute Myeloid Leukemia; immunotherapy; HDC IL-2; NKG2A; NK education; SNPs; NK activating receptors; HLA class I;

    Sammanfattning : Numerous studies have revealed that natural killer cells have fundamental roles as effector cells in myeloid leukemias. Thus, understanding NK cell-related biomarkers that influence clinical outcome are warranted. LÄS MER

  7. 10. NK cell recognition of herpesviruses : mechanisms of viral immune escape

    Författare :Alexander Rölle; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Herpesviruses are ubiquitous pathogens which after an often asymptomatic infection establish lifelong latency in the host. Control of the viral infection depends on both innate and adaptive immune system. LÄS MER