Sökning: "NKG2A"

Visar resultat 1 - 5 av 21 avhandlingar innehållade ordet NKG2A.

1. 1. On the role of Natural Killer cell immunogenetics for the outcome of immunotherapy in acute myeloid leukemia

   Författare :Brwa Ali Hussein; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Natural killer cells; Acute Myeloid Leukemia; immunotherapy; HDC IL-2; NKG2A; NK education; SNPs; NK activating receptors; HLA class I;

   Sammanfattning : Numerous studies have revealed that natural killer cells have fundamental roles as effector cells in myeloid leukemias. Thus, understanding NK cell-related biomarkers that influence clinical outcome are warranted. LÄS MER

3. 2. Immunotherapy and immunosuppression in myeloid leukemia

   Författare :Alexander Hallner; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Natural killer cells; acute myeloid leukemia; histamine dihydrochloride; immunotherapy; reactive oxygen species; chronic myelomonocytic leukemia; NK cell education; NKG2A; HLA; KIR;

   Sammanfattning : Acute myeloid leukemia (AML) and chronic myelomonocytic leukemia (CMML) are potentially life-threatening blood cancers characterized by the expansion of malignant myeloid cells in bone marrow and other organs. This thesis aimed at contributing to the understanding of the role of natural killer (NK) cells in AML and CMML with focus on the potential impact of the immunosuppression exerted by reactive oxygen species (ROS) formed by the myeloid cell NOX2 enzyme. LÄS MER

4. 3. The Role of Plasmacytoid Dendritic Cells and Natural Killer Cells in Systemic Lupus Erythematosus

   Författare :Niklas Hagberg; Lars Rönnblom; Maija-Leena Eloranta; George Tsokos; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systemic lupus erythematosus; plasmacytoid dendritic cells; natural killer cells; type I interferon; immune complex; SLAM receptors; autoantibodies; CD94 NKG2A; CD94 NKG2C; Medicinsk vetenskap; Medical Science; Immunologi; Immunology;

   Sammanfattning : Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibody production, which can eventually lead to immune complex (IC)-mediated organ damage. Due to the stimulation of plasmacytoid dendritic cells (pDC) by nucleic acid-containing ICs (DNA- or RNA-IC), patients with SLE have an ongoing interferon (IFN)-α production. LÄS MER

5. 4. Modulation of natural killer cell and T-cell functions by CD94/NKG2A receptors

   Författare :Cristina Teixeira de Matos; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :NK cells; Dendritic cells; Inhibitory receptors; Cytokines; C1394 NKG2A; HLA-E; Inflammation; Chronic arthritis; Tumor cells.;

   Sammanfattning : Natural Killer (NK) cells constitute a subset of lymphocytes capable of cytokine production and/or cellular cytotoxicity. Although NK cells can be activated experimentally by a multitude of agents, the in vivo mechanisms of activation and regulation are not fully elucidated. LÄS MER

7. 5. The ontogeny and regulation of human natural killer cells

   Författare :Martin A Ivarsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Natural Killer (NK) cells are members of the innate lymphoid cell (ILC) family and take part in the detection and eradication of virus-infected and transformed cells. In this thesis, together with my colleagues I have investigated how NK cells and other ILCs develop and function during human fetal development, how NK cells are functionally regulated (educated) via the activating receptor KIR2DS1, and how NK cells in our body are affected during the early phase of an acute viral infection. LÄS MER