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Visar resultat 1 - 5 av 16 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Modulation of natural killer cell and T-cell functions by CD94/NKG2A receptors

    Författare :Cristina Teixeira de Matos; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NK cells; Dendritic cells; Inhibitory receptors; Cytokines; C1394 NKG2A; HLA-E; Inflammation; Chronic arthritis; Tumor cells.;

    Sammanfattning : Natural Killer (NK) cells constitute a subset of lymphocytes capable of cytokine production and/or cellular cytotoxicity. Although NK cells can be activated experimentally by a multitude of agents, the in vivo mechanisms of activation and regulation are not fully elucidated. LÄS MER

  3. 2. Immunological recognition and tumor escape mechanisms of ovarian carcinoma

    Författare :Håkan Norell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Tumor immunology; Immune escape; Antitumor immunity; Ovarian carcinoma; NK cells; HLA class 1; LOH; IFN-γ; CTL; HLA-G; HLA-E; Activating receptors; NK cell-based therapy;

    Sammanfattning : Ovarian carcinoma is a leading cause of cancer mortality and there is an urgent need for new and better therapeutic modalities that result in improved long-term outcome for this severe malignancy. One promising treatment modality for patients suffering from ovarian carcinoma is immunotherapy. LÄS MER

  4. 3. Mechanisms of immune escape : implications for immunotherapy against cancer

    Författare :Karl-Johan Malmberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Tumor Immunology; Immune escape; NK receptors; T lymphocytes; Oxidative stress; Vitamin E;

    Sammanfattning : Tumor cells can be recognized and killed by cytotoxic T cells specific for certain tumor antigens. Immune mediated selection pressure along with genetic instability of tumor cells result in a growth advantage of tumor cells that acquire a less immunogenic phenotype. LÄS MER

  5. 4. Experimental therapeutics against malignant mesothelioma : investigations in vitro

    Författare :Gustav Nilsonne; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Malignant mesothelioma is a tumour of the mesothelium, a specialized tissue found in the pleura, pericardium, peritoneum, and tunica vaginalis testis. The tumour has strong etiological links to asbestos, with a latency period ranging up to several decades between asbestos exposure and tumour diagnosis. LÄS MER

  7. 5. Molecular specificities of NK cell-mediated recognition of human tumor cells

    Författare :Mattias Carlsten; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Natural killer (NK) cells have been implicated in tumor immune surveillance and can reject transformed cells expressing ligands for activating NK cell receptors and low levels of HLA class I. Although NK cells are well known for their ability to kill tumor cells, relatively few studies have addressed the molecular specificity of NK cell-mediated recognition of freshly isolated human tumor cells. LÄS MER