Sökning: "HLA-DQ2"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet HLA-DQ2.

  1. 1. Aspects of immunogenetics, infections, and nutrition on the risk of celiac disease autoimmunity in an Ethiopian pediatric birth cohort

    Författare :Adugna Negussie Gudeta; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; celiac disease; HLA-DQ2; HLA-DQ8; infection; diet;

    Sammanfattning : Background: Celiac disease (CD) is an immune-mediated inflammatory disease of the intestine in genetically susceptible individuals caused by loss of tolerance to the storage proteins (gluten) in wheat, rye, and barley. Little is known about CD and associated risk factors in Sub-Saharan African countries including Ethiopia. LÄS MER

  3. 2. Perinatal risk factors for type 1 diabetes in children and adolescents

    Författare :Nina Lindell; Ulf Samuelsson; Ann Josefsson; Annelie Carlsson; Mikael Knip; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Background Type 1 diabetes (T1D) is an autoimmune disease characterized by progressive loss of the insulin producing pancreatic β-cells. The disease process starts years before the clinical diagnosis. The cause of T1D is unknown, but it is believed to be a combination of genetic and environmental factors. LÄS MER

  4. 3. Coeliac disease in children and adolescents with type 1 diabetes : screening, diagnosis and prevalence

    Författare :Mara Cerqueiro Bybrant; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Coeliac disease (CD) is more common in children and adolescents with type 1 diabetes (T1D). Both diseases share the same high-risk genes: human leukocyte antigen (HLA) DQ2 and DQ8. Other factors than gluten intake and high-risk genes are necessary to develop CD. LÄS MER

  5. 4. Gut Mucosal Reactivity to Gluten and Cow´s Milk Protein in Rheumatic Diseases

    Författare :Maria Lidén; Roger Hällgren; Gudjón Kristjánsson; Sigrídur Valtýsdóttir; Thomas Skogh; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Primary Sjögren’s syndrome; rheumatoid arthritis; spondyloarthropathies; rectal challenge; food sensitivity; myeloperoxidase; nitric oxide and barrier permeability; Rheumatology; Reumatologi; Medicine; medicin;

    Sammanfattning : This thesis comprised patients with chronic rheumatic diseases. The studies aimed to elucidate food sensitivity by measuring mucosal inflammatory reactivity and thereby a possible link between the gut and joints. LÄS MER

  7. 5. Immunogenetics of Childhood Type 1 Diabetes in Immigrant Patients in Sweden. Migration Studies on Type 1 Diabetes

    Författare :Ahmed Delli; Celiaki och diabetes; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diabetes; Type 1 Diabetes; Childhood; Human Leukocyte Antigen HLA ; Islet autoantibodies; Zinc Transporter 8 ZnT8 ; Islet antigen IA2- ; Glutamic Acid Decarboxylase 65 GAD65; Insulin; Migration.;

    Sammanfattning : This thesis examined whether the offspring of immigrants (non-Swedes) to Sweden are at increased risk of Type 1 Diabetes (T1D) when they are born or live in Sweden. It also evaluated if their T1D and T2D-related genes differed from Swedish patients and whether this genetic heritage determined the types and existence of islet autoantibodies at time of diagnosis and affected the classification of diabetes. LÄS MER