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Visar resultat 1 - 5 av 8 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Analysis of Complex Genetic Traits in Population Cohorts using High-throughput Genotyping Technology

    Författare :Andreas Dahlgren; Ann-Christine Syvänen; Håkan Melhus; Markus Perola; Struan Grant; Uppsala universitet; []
    Nyckelord :Molecular medicine; SNP; TCF7L2; HHEX; COL11A1; ESR1; body height; type 2 diabetes mellitus; proinsulin; ULSAM; complex genetic trait; genotyping technology; Molekylärmedicin;

    Sammanfattning : Most human traits and common diseases have a complex genetic makeup involving more than one gene. The work presented in this thesis investigates standing body height and the common disease type 2 diabetes mellitus (T2DM). LÄS MER

  3. 2. Comparative sequencing of candidate genes in complex disease

    Författare :Shane McCarthy; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :DNA; Sequencing; Complex Disease; Candidate Gene;

    Sammanfattning : Complex multi-factorial diseases such as cardiovascular, metabolic, neurological and respiratory disorders affect a great number of people across the world. In the post-Human Genome Sequencing era, genome wide association studies are increasingly viable alternatives to linkage approaches in locating disease genes. LÄS MER

  4. 3. Genetics and functions of innate-like lymphocyte subsets

    Författare :Julia Rolf; Göteborgs universitet; []
    Nyckelord :innate-like lymphocyte; CD1d; autoimmunity; genetic mapping; microarray; Salmonella infection;

    Sammanfattning : The immune system contains three different branches: innate immunity, adaptive immunity and innate-like lymphocytes that share properties both with the innate and adaptive immune cells. The innate-like lymphocytes have the capacity to rapidly become activated by invading pathogens and also to modulate immune responses and thereby inhibit or promote inflammation. LÄS MER

  5. 4. SNP based strategies to study candidate genes for Alzheimer’s disease

    Författare :Lars Feuk; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Alzheimer s disease; complex disease; SNP; polymorphism; association study; genotyping; DASH;

    Sammanfattning : Alzheimer’s disease (AD) is the most common form of dementia in the elderly. It is a genetically heterogeneous disease characterized by progressive cognitive decline and memory impairment. The rare familial form of AD is caused by three different genes called APP, PSEN1 and PSEN2. LÄS MER

  7. 5. Identification of susceptibility genes in type 2 diabetes

    Författare :Sofia Nordman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Type 2 diabetes; single nucleotide polymorphism; genetic association;

    Sammanfattning : Identification of the susceptibility genes will offer better understanding of molecular mechanisms underlying T2D pathogenesis, and subsequently may lead to development of novel therapeutic approaches. This thesis mainly concerns the genetic association study of four candidate genes. LÄS MER