Sökning: "HHEX"
Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet HHEX.
1. Analysis of Complex Genetic Traits in Population Cohorts using High-throughput Genotyping Technology
Sammanfattning : Most human traits and common diseases have a complex genetic makeup involving more than one gene. The work presented in this thesis investigates standing body height and the common disease type 2 diabetes mellitus (T2DM). LÄS MER
2. Comparative sequencing of candidate genes in complex disease
Sammanfattning : Complex multi-factorial diseases such as cardiovascular, metabolic, neurological and respiratory disorders affect a great number of people across the world. In the post-Human Genome Sequencing era, genome wide association studies are increasingly viable alternatives to linkage approaches in locating disease genes. LÄS MER
3. Genetics and functions of innate-like lymphocyte subsets
Sammanfattning : The immune system contains three different branches: innate immunity, adaptive immunity and innate-like lymphocytes that share properties both with the innate and adaptive immune cells. The innate-like lymphocytes have the capacity to rapidly become activated by invading pathogens and also to modulate immune responses and thereby inhibit or promote inflammation. LÄS MER
4. SNP based strategies to study candidate genes for Alzheimer’s disease
Sammanfattning : Alzheimer’s disease (AD) is the most common form of dementia in the elderly. It is a genetically heterogeneous disease characterized by progressive cognitive decline and memory impairment. The rare familial form of AD is caused by three different genes called APP, PSEN1 and PSEN2. LÄS MER
5. Identification of susceptibility genes in type 2 diabetes
Sammanfattning : Identification of the susceptibility genes will offer better understanding of molecular mechanisms underlying T2D pathogenesis, and subsequently may lead to development of novel therapeutic approaches. This thesis mainly concerns the genetic association study of four candidate genes. LÄS MER