Sökning: "Giant cell"

Visar resultat 6 - 10 av 40 avhandlingar innehållade orden Giant cell.

  1. 6. Clinical and Epidemiological Studies on Giant Cell Arteritis

    Författare :Pavlos Stamatis; Reumatologi och molekylär skelettbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epidemiology; Vasculitis; Risk Factor; Outcomes; Giant cell arteritis; Infection; cancer registries; Malignancies; Myocardial infarction; Incidence; Prevalence; Seasonal variability;

    Sammanfattning : Objectives: The aim of the research summarized in this thesis was to present a comprehensive view of the epidemiology of biopsy-confirmed GCA, investigate infection as a possible risk factor of GCA, and to assess the association of GCA with cancer and myocardial infarction.Methods: To establish incidence and prevalence, patients diagnosed with biopsy-confirmed GCA in Skåne, Sweden 1997–2019 were identified through the database of the pathology department of Region Skåne which serves the entire region. LÄS MER

  3. 7. Studies of Fusion Oncogenes and Genomic Imbalances in Human Tumors

    Författare :Fredrik Persson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer genetics; fusion oncogene; gene amplification; array CGH; PLAG1; HMGA2; FGFR1; MDM2; pleomorphic adenoma; carcinoma ex pleomorphic adenoma; liposarcoma;

    Sammanfattning : Cancer is a genetic disease caused by mutations and chromosome rearrangements affecting oncogenes and tumor suppressor genes in particular. Molecular analyses of recurrent translocations in hematological disorders, as well as in certain solid tumor types, have shown that they frequently result in fusion oncogenes. LÄS MER

  4. 8. New Functions for Old Genes in the Mouse Placenta

    Författare :Umashankar Singh; Reinald Fundele; Anne C Ferguson-Smith; Uppsala universitet; []
    Nyckelord :Developmental biology; hybrid dysgenesis effects; placental hyperplasia; functional screening; giant cell; glycogen cell; Utvecklingsbiologi;

    Sammanfattning : Different species are separated by pre-zygotic reproductive barriers which impede gene flow between them. Rarely, when pre-zygotic barriers break down, interspecific hybrids are produced that display abnormal phenotypes, collectively called hybrid dysgenesis effects. LÄS MER

  5. 9. CD47–SIRPα : an interaction of importance for bone cell differentiation

    Författare :Cecilia Koskinen; Pernilla Lundberg; Per-Arne Oldenborg; Riku Kiviranta; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD47; SIRPalpha; osteoblast; osteoclast; SHP-2; Akt2; cell research; cellforskning;

    Sammanfattning : Bone tissue is continuously remodeled by bone-forming osteoblasts and bone-resorbing osteoclasts, in processes tightly regulated by hormones, cytokines and growth factors. CD47, a ubiquitously expressed protein, and one of its ligands, signal-regulatory protein alpha (SIRPα), are two cell-surface proteins belonging to the immunoglobulin (Ig)-superfamily. LÄS MER

  7. 10. The role of PDGFB in dermatofibrosarcoma protuberans and giant cell fibroblastoma

    Författare :Kevin P O'Brien; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Dermatofibrosarcoma protuberans; giant cell fibroblastoma; translocation; FISH; translocation breakpoint; fusion gene; oncogene; Platelet derived growth factor B-chain; collagen type I alpha 1; tumor formation; autocrine stimulation;

    Sammanfattning : Dermatofibrosarcoma protuberans (DFSP) and giant cell fibroblastoma (GCF) are rare invasive tumors of the dermis. GCF is considered the juvenile form of DFSP. Both DFSP and GCF are characterized by the presence of chromosomal aberrations involving chromosomes 17 and 22. LÄS MER