Sökning: "SIRPalpha"

Hittade 2 avhandlingar innehållade ordet SIRPalpha.

1. 1. CD47–SIRPα : an interaction of importance for bone cell differentiation

   Författare :Cecilia Koskinen; Pernilla Lundberg; Per-Arne Oldenborg; Riku Kiviranta; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD47; SIRPalpha; osteoblast; osteoclast; SHP-2; Akt2; cell research; cellforskning;

   Sammanfattning : Bone tissue is continuously remodeled by bone-forming osteoblasts and bone-resorbing osteoclasts, in processes tightly regulated by hormones, cytokines and growth factors. CD47, a ubiquitously expressed protein, and one of its ligands, signal-regulatory protein alpha (SIRPα), are two cell-surface proteins belonging to the immunoglobulin (Ig)-superfamily. LÄS MER

3. 2. Mechanisms involved in macrophage phagocytosis of apoptotic cells

   Författare :Anna Nilsson; Per-Arne Oldenborg; Karl-Eric Magnusson; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; macrophages; dendritic cells; phagocytosis; apoptotic cells; senescent erythrocytes; CD47; SIRPalpha; LRP1; calreticulin; Immunology; Immunologi; immunologi; Immunology;

   Sammanfattning : Efficient removal of apoptotic cells is critical for development, tissue remodelling, maintenance of homeostasis, and response to injury. Phagocytosis of apoptotic cells is mediated by many phagocytic receptors, soluble bridging molecules, and pro-phagocytic ligands on the surface of apoptotic cells. LÄS MER