Sökning: "FcgammaR"

Hittade 2 avhandlingar innehållade ordet FcgammaR.

  1. 1. Modulation of inflammation by immunostimulatory DNA

    Författare :Jan Bjersing; Göteborgs universitet; []
    Nyckelord :CpG DNA; arthritis; phosphodiester; phosphorothioate; nucleotide modification; cytokines; chemokines; FcgammaR; B cell subsets.;

    Sammanfattning : The aim of this thesis was to elucidate the roles of different types of DNA in inflammatory responses. We compared the immune responses to nuclease-protected phosphorothioate oligodeoxynucleotides (S-ODNs) and phosphodiester oligodeoxynucleotides (O-ODNs) that either contained or lacked CpG motifs. LÄS MER

  3. 2. Hyperreactive peripheral neutrophils in periodontitis : FCc receptor activation and plasma proteins

    Författare :Margareta Fredriksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Periodontitis neutrophils; oxygen radicals; smoking; priming.;

    Sammanfattning : It is now well established that adult and juvenile periodontitis are associated with a hyperreactivity of the peripheral neutrophils when measured as increased generation of free oxygen radicals after stimulation of the Fcgamma-receptors. Aim: The aims of these investigations were to study if the increased radical generation was: 1) located intra- or extracellularly and attributed to a specific oxygen species or various activation pathways, 2) connected with "priming" (pre-stimulation only disclosed by a secondary activation), 3) associated with systemic aberrations in plasma parameters induced by the periodontal disease or cigarette smoking or 4) related to the neutrophil production of the cytokines IL-8 and TNFalpha after stimulation. LÄS MER