Sökning: "nucleotide modification"

Visar resultat 1 - 5 av 24 avhandlingar innehållade orden nucleotide modification.

  1. 1. Modulation of inflammation by immunostimulatory DNA

    Författare :Jan Bjersing; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :CpG DNA; arthritis; phosphodiester; phosphorothioate; nucleotide modification; cytokines; chemokines; FcgammaR; B cell subsets.;

    Sammanfattning : The aim of this thesis was to elucidate the roles of different types of DNA in inflammatory responses. We compared the immune responses to nuclease-protected phosphorothioate oligodeoxynucleotides (S-ODNs) and phosphodiester oligodeoxynucleotides (O-ODNs) that either contained or lacked CpG motifs. LÄS MER

  3. 2. Exotic Ribosomal Enzymology

    Författare :Josefine Liljeruhm; Anthony C. Forster; Christophe Danelon; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; rRNA modification; Methyltransferase; RlmM; RlmJ; D-amino acid; Unnatural amino acid; Chromoprotein; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Sammanfattning : This thesis clarifies intriguing enzymology of the ribosome, the multiRNA/multiprotein complex that catalyzes protein synthesis (translation). The large ribosomal RNAs (23S and 16S rRNAs in E. coli) are post-transcriptionally modified by many specific modification enzymes, yet the functions of the modifications remain enigmatic. LÄS MER

  4. 3. A Bioinformatics Study of Human Transcriptional Regulation

    Författare :Adam Ameur; Jan Komorowski; Claes Wadelius; Philipp Bucher; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; microarray; ChIP-chip; ChIP-seq; transcription factor; histone modification; motif search; Bioinformatics; Bioinformatik;

    Sammanfattning : Regulation of transcription is a central mechanism in all living cells that now can be investigated with high-throughput technologies. Data produced from such experiments give new insights to how transcription factors (TFs) coordinate the gene transcription and thereby regulate the amounts of proteins produced. LÄS MER

  5. 4. Frameshifting as a tool in analysis of transfer RNA modification and translation

    Författare :Ramune Leipuviene; Glenn Björk; Diana Downs; Umeå universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; minor tRNA; frameshifting; suppression; L9; hopping; tRNA thiolation; [Fe-S] cluster; [Fe-S] protein; TtcA; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Studies of ribosomal reading frame maintenance are often based on frameshift mutation suppression experiments. In this thesis, suppression of a frameshift mutation in Salmonella enterica serovar Typhimurium by a tRNA and a ribosomal protein are described. LÄS MER

  7. 5. Roles of NUDT5 and NUDT15 beyond oxidized nucleotide sanitation and their potential as therapeutic targets

    Författare :Nicholas Carl Kristoffer Valerie; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The nucleotide precursor pool is readily susceptible to numerous sources of modification and damage, including alkylation, deamination and oxidation/nitrosylation, among others; most of which have deleterious effects on nucleic acid integrity and cellular fitness. In addition to DNA repair mechanisms, these metabolic byproducts are kept in check by so-called sanitation or “housekeeping” enzymes, chief among them the NUDIX hydrolase superfamily. LÄS MER