Sökning: "phosphodiester"

Visar resultat 1 - 5 av 16 avhandlingar innehållade ordet phosphodiester.

  1. 1. Modulation of inflammation by immunostimulatory DNA

    Författare :Jan Bjersing; Göteborgs universitet; []
    Nyckelord :CpG DNA; arthritis; phosphodiester; phosphorothioate; nucleotide modification; cytokines; chemokines; FcgammaR; B cell subsets.;

    Sammanfattning : The aim of this thesis was to elucidate the roles of different types of DNA in inflammatory responses. We compared the immune responses to nuclease-protected phosphorothioate oligodeoxynucleotides (S-ODNs) and phosphodiester oligodeoxynucleotides (O-ODNs) that either contained or lacked CpG motifs. LÄS MER

  3. 2. Synthesis of phosphate-containing oligosaccharides corresponding to capsular antigen structures from Haemophilus influenzae

    Författare :Jonas Hansson; J.S Brimacombe; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic Chemistry; organisk kemi;

    Sammanfattning : This thesis describes the synthesis of spacer-equipped di- and trimeric oligosaccharide structures corresponding to fragments of the capsular polysaccharides of Haemophilus influenzae types c and f. Both of these polysaccharides are of the teichoic acid type, built up by disaccharide repeating units linked via interglycosidic phosphodiester bonds. LÄS MER

  4. 3. Placental Function : An Epidemiological and Magnetic Resonance Study

    Författare :Sara Sohlberg; Anna-Karin Wikstrom; Matts Olovsson; Ajlana Mulic-Lutvica; Johan Wikström; Karel Marsal; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; body height; body mass index; early preeclampsia; late preeclampsia; magnetic resonance imaging; placenta; perfusion; IVIM; risk factors; energy metabolism; magnetic resonance spectroscopy; 31P-MRS; Obstetrik och gynekologi; Obstetrics and Gynaecology;

    Sammanfattning : Placental function is central for normal pregnancy and in many of the major pregnancy disorders. We used magnetic resonance imaging techniques to investigate placental function in normal pregnancy, in early and late preeclampsia and in intrauterine growth restriction. LÄS MER

  5. 4. Studies on oligodeoxyribonucleotide (DNA) chemistry

    Författare :Neil Balgobin; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : This communication discusses some of the more common problems encountered in the chemical synthesis of oligodeoxyribonucleotides. Several new protecting groups are introduced, such as the 2-phenylsulphonylethyl and the fluoren-9-methyl, for terminal phosphodiester protection, during the block synthesis of oligodeoxyribonucleotides, following the Catlin-Cramer approach. LÄS MER

  7. 5. Radiolabelled Oligonucleotides for Evaluation of in vivo Hybridisation Utilising PET Methodology

    Författare :Gábor Lendvai; Mats Bergström; Sergio Estrada; Barbro Eriksson; Raymond Josephsson; Bertrand Tavitian; Uppsala universitet; []
    Nyckelord :Molecular medicine; Gene expression; Antisense oligonucleotides; Positron emission tomography; In vivo hybridisation; In vivo biodistribution; Chromogranin-A; 68Ga; RT-PCR; Scavenger receptors; Molekylärmedicin;

    Sammanfattning : Antisense oligonucleotides (ODN) may interfere in gene expression on the basis of hybridising to its complementary messenger RNA (mRNA) sequence in the cell thereby preventing the synthesis of the peptide. Therefore, these ODNs may be potential drugs to treat human diseases by “knocking down” the expression of responsible genes or correcting the maturation process of mRNA in the field called antisense therapy. LÄS MER