Sökning: "CpG DNA"

Visar resultat 1 - 5 av 78 avhandlingar innehållade orden CpG DNA.

  1. 1. Arthritogenic property of bacterial DNA containing CpG motifs

    Detta är en avhandling från Göteborg

    Författare :Guo-Min Deng; Göteborgs universitet.; Gothenburg University.; [2001]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bacterial DNA; CpG ODN; arthritis; macrophage; lymphocytes; TNFa; NF-kB; mice;

    Sammanfattning : .... LÄS MER

  2. 2. Modulation of inflammation by immunostimulatory DNA

    Detta är en avhandling från Göteborg

    Författare :Jan Bjersing; Göteborgs universitet.; Gothenburg University.; [2004]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CpG DNA; arthritis; phosphodiester; phosphorothioate; nucleotide modification; cytokines; chemokines; FcgammaR; B cell subsets.;

    Sammanfattning : The aim of this thesis was to elucidate the roles of different types of DNA in inflammatory responses. We compared the immune responses to nuclease-protected phosphorothioate oligodeoxynucleotides (S-ODNs) and phosphodiester oligodeoxynucleotides (O-ODNs) that either contained or lacked CpG motifs. LÄS MER

  3. 3. DNA vaccines and bacterial DNA in immunity

    Detta är en avhandling från Stockholm : Karolinska Institutet, Microbiology and Tumor Biology Center (MTC)

    Författare :Lisa Charlotta Bandholtz; Karolinska Institutet.; Karolinska Institutet.; [2002]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA vaccine; CpG DNA; antimicrobial peptides C. pneumoniae; Shigella spp;

    Sammanfattning : This thesis describes DNA-based vaccination and the importance of bacterial DNA in different immunological perspectives. Intranasal (i.n.) DNA vaccination utilizing a plasmid encoding the chlamydial heat shock protein 60 (p-hsp-60) generated lower bacterial burden and reduced pathology in the lungs of mice after subsequent infection with C. LÄS MER

  4. 4. Inflammatogenic properties of endogenous DNA

    Detta är en avhandling från Stockholm : Karolinska Institutet, Microbiology and Tumor Biology Center (MTC)

    Författare :Shahin Hajizadeh; Göteborgs universitet.; Gothenburg University.; [2004]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inflammation; mtDNA; oxidized DNA; SF; CSF; RA; dementia;

    Sammanfattning : Bacterial DNA and CpG-containing oligodeoxynucleotides (ODNs) induce host inflammatory responses as a result of their content of unmethylated ¡§CpG motifs¡¨. Since the CpG motifs in the mitochondrial (mt) genome are in this respect similar to bacterial DNA, in that they are non-methylated, we investigated whether mtDNA also displays inflammatogenic potential. LÄS MER

  5. 5. The CpG island methylator phenotype in colorectal cancer studies on risk and prognosis

    Detta är en avhandling från Umeå : Umeå university

    Författare :Anna Dahlin; Umeå universitet.; Umeå universitet.; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal cancer; DNA methylation; folate; microsatellite instability MSI ; prognosis; risk factors; t-lymphocytes; the CpG island methylator phenotype CIMP ; Vitamin B12; MEDICINE Morphology; cell biology; pathology Pathology; MEDICIN Morfologi; cellbiologi; patologi Patologi; MEDICINE Morphology; cell biology; pathology Morphology Tumour biology; MEDICIN Morfologi; cellbiologi; patologi Morfologi Tumörbiologi; patologi; Pathology;

    Sammanfattning : Background Colorectal cancer (CRC) is the second most common malignancy in developed countries. The mortality is high, with nearly half of patients dying from the disease. The primary treatment of CRC is surgery, and decisions about additional treatment with chemotherapy are based mainly on tumor stage. LÄS MER