Sökning: "phosphorothioate"

Visar resultat 1 - 5 av 18 avhandlingar innehållade ordet phosphorothioate.

  1. 1. Modulation of inflammation by immunostimulatory DNA

    Författare :Jan Bjersing; Göteborgs universitet; []
    Nyckelord :CpG DNA; arthritis; phosphodiester; phosphorothioate; nucleotide modification; cytokines; chemokines; FcgammaR; B cell subsets.;

    Sammanfattning : The aim of this thesis was to elucidate the roles of different types of DNA in inflammatory responses. We compared the immune responses to nuclease-protected phosphorothioate oligodeoxynucleotides (S-ODNs) and phosphodiester oligodeoxynucleotides (O-ODNs) that either contained or lacked CpG motifs. LÄS MER

  3. 2. Studies on formation and stability of phosphorothioate RNA

    Författare :Helena Almer; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Synteser och reaktioner;

    Sammanfattning : .... LÄS MER

  4. 3. Evaluation, synthesis and imaging of therapeutic oligonucleotides

    Författare :Rouven Stulz; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : A new method for the ³⁴S isotope labelling of phosphorothioate oligonucleotides is reported which allows a practical synthesis of site specifically labeled oligonucleotides. Several applications of this method are reported. LÄS MER

  5. 4. Synthesis of 18F- and 76Br-labelled oligonucleotide and nucleoside derivatives

    Författare :Elisabeth Hedberg; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemistry; Kemi; Chemistry; Kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : With the aim of developing synthetic routes to oligodeoxynucleotides and analogues labelled with the positron-emitting radionuclides 18F and 76Br (half-lives 1.8 and 16. LÄS MER

  7. 5. Studies on the synthesis of nucleotide analogues containing P-F and P-Se bonds

    Författare :Martin Bollmark; Janusz Rachon; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic Chemistry; organisk kemi;

    Sammanfattning : In the present work, new synthetic approaches to the synthesis of nucleoside phosphorofluoridate and phosphorofluoridothioate diesters have been developed. These procedures involve either oxidative transformation of the corresponding H-phosphonate or H-phosphonothioate diesters in the presence of fluoride anion or iodine-promoted desulfurization of phosphorothioate or phosphorodithioate diesters in the presence of fluoride anion. LÄS MER