Sökning: "Chemoattractant receptors"

Visar resultat 1 - 5 av 26 avhandlingar innehållade orden Chemoattractant receptors.

  1. 1. Recognition by leukocyte formyl peptide receptors. Promiscuous binding or pattern recognition?

    Författare :Johan Bylund; Göteborgs universitet; []
    Nyckelord :neutrophils; chemoattractant; FPRL1; NADPH-oxidase; LPS; priming; subcellular organelles; human; murine;

    Sammanfattning : Neutrophil granulocytes play an important role in the early stages of microbial infection. The neutrophils have to leave the blood stream and migrate out into the tissue where they phagocytose microbes and cell debris from damaged host tissues. LÄS MER

  3. 2. Functional importance of estrogen receptors in the periodontium

    Författare :Daniel Nebel; Malmö högskola; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Estrogen; Estrogen receptors; LPS; Periodontium; PDL cells; Gingival epithelial cells;

    Sammanfattning : Östrogen är ett kvinnligt könshormon som även har andra effekter. Östrogen verkar i cellkärnan genom att binda till en östrogenreceptor (ER), som finns i två olika typer, ERα och ERβ. Parodontit (tandlossning) är en inflammationssjukdom som drabbar tandens fäste som svar på bakterier som normalt finns i munhålan. LÄS MER

  4. 3. Activation of professional phagocytes with emphasis on the formyl peptide receptor family

    Författare :Jennie Karlsson; Göteborgs universitet; []
    Nyckelord :phagocyte; G-protein coupled receptor; chemoattractant; formyl peptide receptor; reactive oxygen species; calcium;

    Sammanfattning : Phagocytic cells such as neutrophil granulocytes and monocytes are an essential part of our innate immune system and play an important role in the battle against pathogens. G-protein coupled receptors (GPCRs) and more specifically chemoattractant receptors are a vital part in guiding phagocytes towards the site of infection. LÄS MER

  5. 4. Chemoattractant receptors in drug discovery : FPR2 and CCR2-two potential targets

    Författare :Christina Kalderén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chemoattractants and chemoattractant receptors have many important functions in multicellular organisms, not least for their role in regulating migration of leukocytes. The receptors are also involved in many pathologies and they have, since they were cloned in the 1990ies, been regarded as attractive targets for development of drugs against cancer, viral infections, and inflammatory/autoimmune diseases. LÄS MER

  7. 5. Chemoattractant receptor signaling and neutrophil acctivation. Involvement of the cytoskeleton

    Författare :Huamei Fu; Göteborgs universitet; []
    Nyckelord :neutrophils; G-protein coupled receptors; signaling; cytoskeleton;

    Sammanfattning : Neutrophil granulocytes play a vital role in the host surveillance system and form the first line of defense against microbial infections. The migration of neutrophils to an infected/inflamed tissue is guided by chemoattractants released either from intruding microbes or from activated/damaged host cells. LÄS MER