Sökning: "Cancer-associated fibroblast CAF"

Hittade 3 avhandlingar innehållade orden Cancer-associated fibroblast CAF.

1. 1. The identification and functional evaluation of novel cancer-associated fibroblast subtypes and matrisome proteins in pancreatic cancer

   Författare :Joshua Cumming; Daniel Öhlund; Cedric Patthey; Jenny Persson; Claus Jørgensen; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer-associated fibroblast CAF ; Single-cell RNA sequencing scRNAseq ; Pancreatic ductal adenocarcinoma PDAC ; Tumor microenvironment TME ; Extracellular matrix ECM ; Organoid-based co-culture model; Drug-screen; Oncology; onkologi;

   Sammanfattning : Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy characterized by an extensive desmoplastic stroma. The stroma is the site of intricate communication between malignant cells and their surrounding environment. LÄS MER

3. 2. Studies on the roles of stromal CXCL14 in tumor growth, progression and metastasis formation

   Författare :Elin Sjöberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Cancer consists of several diseases that are characterized by accumulation of genetic and epigenetic alterations that provide cells with certain capabilities to form tumors. Among these acquired capabilities are enhanced invasion that allow cancer cells to escape from the primary tumor, enter the circulation and eventually reach distant tissues where they form metastasis. LÄS MER

4. 3. Analysis of stroma-derived factors with potential prognostic and therapeutic significance in prostate cancer

   Författare :Christina Hägglöf; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Prostate cancer is the most common malignancy in Sweden with about 9000 new cases diagnosed every year. New markers are needed to improve diagnostic accuracy. The most commonly used tissue-biomarkers are basal cell markers and AMACR, often used in combination. LÄS MER