Sökning: "CaMKII"

Visar resultat 11 - 15 av 25 avhandlingar innehållade ordet CaMKII.

  1. 11. Skeletal muscle calcium homeostasis during fatigue : modulation by kinases and mitochondria

    Författare :Jan Aydin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The use of skeletal muscles in daily activities and even during strenuous exercise resulting in fatigue requires precise regulation of force and the timing of contraction. To achieve such performance characteristics, vertebrate skeletal muscles have developed a unique control mechanism for regulating the free Ca2+ concentration in their myoplasm ([Ca2+]i). LÄS MER

  3. 12. New insights in parathyroid hormone secretion : with focus on exocytosis and calcium signaling

    Författare :Ming Lu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The parathyroid is distinguished from other endocrine systems since its primary stimuli inhibit hormone secretion. It is generally considered that extracellular Ca2+ binds to a membrane receptor (calcium sensing receptor, or CaSR), and via second messengers modulate parathyroid hormone (PTH) secretion. LÄS MER

  4. 13. Developmental Neurotoxicity of Environmental Pollutants : Effects on neuronal protein markers after neonatal exposure

    Författare :Iwa Lee; Henrik Viberg; Elena Jazin; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental neurotoxicity; Neonatal exposure; Protein markers; Environmental pollutants; Biologi med inriktning mot ekotoxikologi; Biology with specialization in Environmental Toxicology;

    Sammanfattning : This thesis focused on investigations of the developmental neurotoxic effects of bisphenol A (BPA) or perfluorohexane sulfonate (PFHxS), after a single neonatal exposure, during a critical period of the brain development in mice.BPA is a well-known industrial chemical used in the production of polymer products and PFHxS is used as an industrial additive as a surfactant. LÄS MER

  5. 14. Neonatal Exposure to Anaesthesia and Adjuvants : Acute Effects on Cerebral Apoptosis and Neuroproteins, and Late  Behavioural Aberrations in Mice

    Författare :Emma Pontén; Anders Fredriksson; Torsten Gordh; Steen Henneberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; anaesthesia; neonatal; apoptosis; bahaviour; clonidine; ketamine; propofol; theophyllamine; Medicin; Medicine;

    Sammanfattning : During a finite developmental phase – the brain growth spurt – the brain grows and matures at an accelerated rate. During this period the brain is more sensitive to harmful substances such as ethanol and environmental toxins than before or after. LÄS MER

  7. 15. Studies on aquaporin 4 : a molecular determinant of brain water homeostasis

    Författare :Eli Gunnarson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : A well controlled brain water homeostasis is of utmost importance for an appropriate control of neuronal activity. Astrocytes express the water channel aqauporin 4 (AQP4) and play a key role for the maintenance of brain water homeostasis. Brain edema is a result of perturbed water homeostasis and involves astrocyte swelling. LÄS MER