Sökning: "CaMKII"
Visar resultat 16 - 20 av 25 avhandlingar innehållade ordet CaMKII.
16. On the Nature of β-Amyloid at Synapses
Sammanfattning : Alzheimer’s disease is an aging related disorder of the mind, accountable for 60-80 percent of all cases of dementia. With its insidious progression and the decline of cognitive abilities, this disease is a major challenge for our society as a whole. LÄS MER
17. Molecular Characterization of Experimental Traumatic Brain Injury
Sammanfattning : Traumatic brain injury (TBI) is the most common cause of mortality and disability in the younger (.... LÄS MER
18. Neonatal Exposure to Highly Brominated Diphenyl Ethers and Perfluorinated Compounds : Developmental Dependent Toxicity and Interaction
Sammanfattning : This thesis investigated the developmental neurotoxic effects of neonatal exposure to highly brominated diphenyl ethers (PBDEs) and perfluorinated compounds (PFCs), alone or in combinations, during a critical period of the brains’ rapid growth and development, in mice. The compounds investigated were the decaBDE (PBDE 209), nonaBDE (PBDE 206), octaBDE (PBDE 203), heptaBDE (PBDE 183), and three PFCs, PFOS, PFOA, and PFDA. LÄS MER
19. Cardiac lipids and their role in the diseased heart
Sammanfattning : Lipids play an essential role within the heart as they are involved in energy storage, membrane stability and signaling. Changes in cardiac lipid composition and utilization may thus have profound effects on cardiac function. Importantly, the diseased heart is associated with intracellular metabolic abnormalities, including accumulation of lipids. LÄS MER
20. Regulation of insulin secretion in diabetes: Molecular mechanism and applications
Sammanfattning : Diabetes is a highly ageing-related disease manifesting with a deteriorated capacity of insulin secretion and uncontrolled blood glucose-raising, hyperglycemia. In this thesis, we aim to explore the underlying roles of CaV channels and aging-associated genetic changes in the development of Type 2 diabetes (T2D). LÄS MER