Sökning: "CYP2C8"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet CYP2C8.

  1. 1. Pharmacogenetic Studies of Paclitaxel in Ovarian Cancer : focus on interindividual differences in pharmacodynamics and pharmacokinetics

    Författare :Henrik Green; Curt Peterson; Peter Söderkvist; Per Rosenberg; Håkan Melhus; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacogenetics; paclitaxel; LC MS; Taxol; ovarian cancer; pharmacokinetics; CYP2C8; CYP3A4; ABCB1; äggstockscancer; paklitaxel; Clinical pharmacology; Klinisk farmakologi;

    Sammanfattning : Ovarian cancer is one of the most common female cancer diseases in the world today and in Sweden more than 800 new cases are diagnosed every year. The standard treatment consists of chemotherapy with paclitaxel in combination with carboplatin after initial cytoreductive surgery. LÄS MER

  3. 2. Genetic polymorphisms in breast cancer in relation to risk and prognosis

    Författare :Erika Bågeman; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; age at diagnosis; breast cancer; polymorphism; CYP1A2; IGF1; GSTM1; CYP2C9; CYP2C8; coffee; GSTT1; ER; parity;

    Sammanfattning : Breast cancer is the most common cancer in women living in Sweden and the second most common cancer in the rest of the world. The risk of developing breast cancer is modified by environment, lifestyle, genetics and a combination of these factors. LÄS MER

  4. 3. Integration of Tumor and Host Factors – Implications for Breast Cancer Prognosis

    Författare :Maria Simonsson; Tumörmikromiljö; []
    Nyckelord :Breast Cancer; Prognosis and survival; CYP1A2; CYP2C8; Coffee Consumption; Alcohol Consumption; Cyclooxygenase-2 COX-2 ;

    Sammanfattning : Breast cancer is the most common cancer among women worldwide, although the mortality rates have decreased in the last decades. Breast cancer is a heterogeneous disease, and treatment resistance is a significant clinical problem in spite of the overall high survival rates. LÄS MER

  5. 4. Interindividual variation in drug metabolism with focus on polymorphic cytochrome P450 2C9

    Författare :Mia Sandberg Lundblad; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cytochromes P450 (CYP) are enzymes, mainly catalysing the oxidation of xenobiotics, in order to facilitate their excretion from the body. CYP2C9 is a polymorphic enzyme, which is responsible for the metabolism of about 10 % of all known drugs, e. LÄS MER

  7. 5. Cytochrome P450 pharmacogenetics : implications for anticancer and warfarin therapy

    Författare :Mi-Young Lee; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : There is a pronounced interindividual variability in the drug disposition, response and toxicity. Pharmacogenetics aims at identifying genetic biomarkers that could help to increase the drug efficacy, reduce adverse drug reactions and contribute to the development of personalized medicine. LÄS MER