Sökning: "GSTT1"

Visar resultat 1 - 5 av 14 avhandlingar innehållade ordet GSTT1.

  1. 1. Genetic polymorphisms, IGF-1, and oral contraceptive use in women from high-risk breast cancer families

    Detta är en avhandling från Department of Oncology, Clinical Sciences, Lund University

    Författare :Maria Henningson; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; familial breast cancer; premenopausal women; htSNP; GSTP1; polymorphism; BRCA1; BRCA2; IGF-1; oral contraceptives; CYP17; GSTT1; GSTM1;

    Sammanfattning : Popular Abstract in Swedish Bröstcancer är den vanligaste cancerformen bland svenska kvinnor, fler än 7000 kvinnor insjuknar varje år. Mellan 5-10% av bröstcancerfallen tros bero på mutationer i arvsmassan som ärvts från föräldrarna. LÄS MER

  2. 2. Genetic polymorphisms in breast cancer in relation to risk and prognosis

    Detta är en avhandling från Department of Oncology, Clinical Sciences, Lund University

    Författare :Erika Bågeman; Lunds universitet.; Lund University.; [2008]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; age at diagnosis; breast cancer; polymorphism; CYP1A2; IGF1; GSTM1; CYP2C9; CYP2C8; coffee; GSTT1; ER; parity;

    Sammanfattning : Breast cancer is the most common cancer in women living in Sweden and the second most common cancer in the rest of the world. The risk of developing breast cancer is modified by environment, lifestyle, genetics and a combination of these factors. LÄS MER

  3. 3. Significance of polymorphisms in human xenobiotic metabolising enzymes

    Detta är en avhandling från Stockholm : Karolinska Institutet, Institute of Enviromental Medicine

    Författare :Anna-Karin Alexandrie; Karolinska Institutet.; Karolinska Institutet.; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Cigarette smoke is the primary cause of lung cancer but urban air pollution and certain occupational exposures have also been found to elevate the incidence of lung cancer. These exposures contain polycyclic aromatic hydrocarbons (PAH), which can be metabolically activated to highly reactive compounds capable of binding to DNA and initiating the carcinogenic process unless they are eliminated. LÄS MER

  4. 4. Autoantigens in Inflammatory Bowel Disease and Primary Sclerosing Cholangitis

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Brita Ardesjö; Uppsala universitet.; [2008]
    Nyckelord :Molecular medicine; inflammatory bowel disease; primary sclerosing cholangitis; autoimmunity; autoantigen; goblet cell; Molekylärmedicin;

    Sammanfattning : Inflammatory bowel disease (IBD) comprises diseases that are characterized by chronic or relapsing inflammation of the gastrointestinal tract. Primary sclerosing cholangitis (PSC) is an extraintestinal manifestation in IBD. LÄS MER

  5. 5. Cryptogenic Polyneuropathy Clinical, Environmental, And Genetic Studies

    Detta är en avhandling från Linköping : Linköping University Electronic Press

    Författare :Jonas Lindh; Linköpings universitet.; Linköpings universitet.; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuropathy; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Internal medicine Neurology; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Invärtesmedicin Neurologi;

    Sammanfattning : Objectives: The purpose of this medical thesis was to describe the clinical and neurophysiological features and to evaluate the health related quality of life (HR-QoL) in patients with cryptogenic polyneuropathy. We also wanted to investigate different occupational, and leisure time exposures as determinants for cryptogenic polyneuropathy, and to analyze whether polymorphisms for the null alleles of Glutathione S-Transferase Mu-1 (GSTM1), and Theta-1 (GSTT1), and a low activity genetic variation of epoxide hydrolase (EPHX) affect the risk of developing polyneuropathy. LÄS MER